Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2471756..2471940 Replicon chromosome
Accession NZ_CP038183
Organism Staphylococcus aureus strain MJ015

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag E3306_RS12320 Protein ID WP_000482652.1
Coordinates 2471833..2471940 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2471756..2471816 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3306_RS12305 2467211..2467378 - 168 WP_001789205.1 hypothetical protein -
E3306_RS12310 2467609..2469342 - 1734 WP_173950615.1 ABC transporter ATP-binding protein/permease -
E3306_RS12315 2469367..2471130 - 1764 WP_001064837.1 ABC transporter ATP-binding protein/permease -
- 2471756..2471816 + 61 - - Antitoxin
E3306_RS12320 2471833..2471940 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
E3306_RS12325 2472074..2472460 - 387 WP_000779357.1 flippase GtxA -
E3306_RS12330 2472728..2473870 + 1143 WP_001176863.1 glycerate kinase -
E3306_RS12335 2473930..2474589 + 660 WP_000831298.1 membrane protein -
E3306_RS12340 2474771..2475982 + 1212 WP_001191922.1 multidrug effflux MFS transporter -
E3306_RS12345 2476105..2476578 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T120788 WP_000482652.1 NZ_CP038183:c2471940-2471833 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T120788 NZ_CP038183:c2471940-2471833 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT120788 NZ_CP038183:2471756-2471816 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References