Detailed information of TA system TA120780

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2013333..2013640
• Replicon: chromosome
• Accession: NZ_CP038183
• Organism: Staphylococcus aureus strain MJ015

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3306_RS09880
• Protein ID: WP_011447039.1
• Coordinates: 2013464..2013640 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2013333..2013472 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3306_RS09840	2008899..2009078	+	180	WP_000669791.1	hypothetical protein	-
E3306_RS09845	2009389..2009649	+	261	WP_001791826.1	hypothetical protein	-
E3306_RS09850	2009702..2010052	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
E3306_RS09855	2010563..2010898	-	336	Protein_1902	SH3 domain-containing protein	-
E3306_RS09860	2011549..2012040	-	492	WP_000920038.1	staphylokinase	-
E3306_RS09865	2012231..2012986	-	756	WP_000861038.1	CHAP domain-containing protein	-
E3306_RS09870	2012998..2013252	-	255	WP_000611512.1	phage holin	-
E3306_RS09875	2013304..2013411	+	108	WP_031762631.1	hypothetical protein	-
-	2013333..2013472	+	140	NuclAT_0	-	Antitoxin
-	2013333..2013472	+	140	NuclAT_0	-	Antitoxin
-	2013333..2013472	+	140	NuclAT_0	-	Antitoxin
-	2013333..2013472	+	140	NuclAT_0	-	Antitoxin
E3306_RS09880	2013464..2013640	-	177	WP_011447039.1	putative holin-like toxin	Toxin
E3306_RS09885	2013843..2014616	-	774	WP_044033830.1	staphylococcal enterotoxin type P	-
E3306_RS09890	2015037..2015411	-	375	WP_000340977.1	hypothetical protein	-
E3306_RS09895	2015467..2015754	-	288	WP_001040255.1	hypothetical protein	-
E3306_RS09900	2015801..2015953	-	153	WP_000654329.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / sak / see / hlb / groEL / hld	1959166..2080567	121401

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T120780 WP_011447039.1 NZ_CP038183:c2013640-2013464 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T120780 NZ_CP038183:c2013640-2013464 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT120780 NZ_CP038183:2013333-2013472 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin