Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1379501..1380065 Replicon chromosome
Accession NZ_CP038153
Organism Lacticaseibacillus paracasei strain TCS

Toxin (Protein)


Gene name yafQ Uniprot ID A0A6G9EML4
Locus tag E3E17_RS07505 Protein ID WP_014951859.1
Coordinates 1379763..1380065 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag E3E17_RS07500 Protein ID WP_003570051.1
Coordinates 1379501..1379770 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3E17_RS07470 1374505..1375392 - 888 WP_012491506.1 ABC transporter ATP-binding protein -
E3E17_RS07475 1375590..1376816 - 1227 WP_012491507.1 hypothetical protein -
E3E17_RS07480 1377014..1377418 + 405 WP_012491508.1 MerR family transcriptional regulator -
E3E17_RS07485 1377411..1377737 + 327 WP_012491509.1 YrdB family protein -
E3E17_RS07490 1377800..1378429 + 630 WP_012491510.1 DUF2399 domain-containing protein -
E3E17_RS07495 1378474..1379127 + 654 WP_012491511.1 GNAT family N-acetyltransferase -
E3E17_RS07500 1379501..1379770 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E3E17_RS07505 1379763..1380065 + 303 WP_014951859.1 type II toxin-antitoxin system YafQ family toxin Toxin
E3E17_RS16690 1380404..1380547 + 144 WP_003574774.1 hypothetical protein -
E3E17_RS07510 1380665..1381357 + 693 WP_012491513.1 hypothetical protein -
E3E17_RS07515 1381593..1383770 + 2178 WP_012491514.1 RNA-binding transcriptional accessory protein -
E3E17_RS07520 1383835..1384764 - 930 WP_003599410.1 IS30-like element ISLpl1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1383835..1384764 929


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11441.27 Da        Isoelectric Point: 10.2818

>T120728 WP_014951859.1 NZ_CP038153:1379763-1380065 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELHVDGPRGDWLLIYKIK
QQDLILTLVRTGSHHNLLGK

Download         Length: 303 bp

>T120728 NZ_CP038153:1379763-1380065 [Lacticaseibacillus paracasei]
ATGTATAGTCTGGTTCCGACGCCTACATTTAAGCGCGATCTAAAACGACTCTCCAAGAAGCATTGGCCGATGGACGAACT
AAAGACGGCTGTTAATCTCCTAGCTGCTGGTACAAATGCTGAACTATTAAGCAAAAAGTATGCAGATCATGCCTTGTCTT
CAAGCAGCGAGTGGAAAGGATATCGTGAACTACATGTTGACGGCCCTCGTGGCGACTGGTTGCTAATCTATAAAATTAAG
CAGCAAGATCTCATTTTGACCCTGGTTAGAACTGGATCTCATCATAACCTTTTGGGTAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT120728 WP_003570051.1 NZ_CP038153:1379501-1379770 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT120728 NZ_CP038153:1379501-1379770 [Lacticaseibacillus paracasei]
ATGGCAGCCACAAAGAAAGAAACTCGCTTGAATATTCGTGTTGATCCGGAATTAAAAAGTGCTGCTCAAATCGTAGCAAA
TGATATGGGCATCGACTTGACCGCAGCTGTTACTATGTTCATGACGAAAATGGTGAAAGATCACGCCCTCCCGTTTACCC
CAACAAGTCTACCAGTTGAAACCTTACAGGCGCTGAAAGAAGCAAAGCACCCAGAGCTGCTCAAAAAATACAGCACGCCT
GATGACATGTGGAGAGACTTGAATGTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G9EML4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References