Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2221483..2222076 Replicon chromosome
Accession NZ_CP038033
Organism Nitrosococcus wardiae strain D1FHS

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E3U44_RS10825 Protein ID WP_134358189.1
Coordinates 2221483..2221761 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E3U44_RS10830 Protein ID WP_134358191.1
Coordinates 2221774..2222076 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3U44_RS10790 2216681..2217079 + 399 WP_134358179.1 hypothetical protein -
E3U44_RS10795 2217072..2217479 + 408 WP_206054756.1 hypothetical protein -
E3U44_RS10800 2217543..2217758 + 216 WP_134358181.1 hypothetical protein -
E3U44_RS10805 2217758..2217946 + 189 WP_134358183.1 hypothetical protein -
E3U44_RS19310 2218119..2218292 + 174 WP_166805058.1 hypothetical protein -
E3U44_RS10810 2218327..2219478 - 1152 Protein_2139 IS4 family transposase -
E3U44_RS10815 2219580..2219891 + 312 WP_134358185.1 hypothetical protein -
E3U44_RS10820 2220006..2221121 - 1116 WP_134358187.1 Fic family protein -
E3U44_RS10825 2221483..2221761 + 279 WP_134358189.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3U44_RS10830 2221774..2222076 + 303 WP_134358191.1 HigA family addiction module antidote protein Antitoxin
E3U44_RS10835 2223035..2223346 + 312 WP_134358192.1 hypothetical protein -
E3U44_RS10840 2223816..2224337 - 522 WP_134358194.1 hypothetical protein -
E3U44_RS10845 2224550..2225371 + 822 WP_134358196.1 extracellular solute-binding protein -
E3U44_RS19315 2225381..2225530 - 150 WP_166805059.1 hypothetical protein -
E3U44_RS10850 2225539..2226264 - 726 WP_134358198.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2196176..2224337 28161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10824.28 Da        Isoelectric Point: 9.9542

>T120686 WP_134358189.1 NZ_CP038033:2221483-2221761 [Nitrosococcus wardiae]
MIKSFRCQETQRLFETGKSRRWQSIRKVAERKLVQLNNARELRDLASPPGNQLETLEGDRAGQHSIRINKQWRVCFVWTS
EGPEAVEIVDYH

Download         Length: 279 bp

>T120686 NZ_CP038033:2221483-2221761 [Nitrosococcus wardiae]
ATGATCAAGAGCTTCCGCTGCCAAGAGACCCAACGTCTGTTTGAAACCGGCAAATCCCGCCGGTGGCAAAGCATTCGCAA
GGTGGCAGAGCGCAAGCTCGTTCAATTGAACAATGCGCGGGAGCTACGGGACCTAGCCTCTCCGCCAGGCAACCAACTGG
AGACATTGGAAGGCGACCGCGCTGGACAGCACAGTATCCGCATCAATAAGCAGTGGCGGGTGTGCTTTGTCTGGACGAGC
GAGGGGCCGGAGGCCGTTGAAATTGTGGACTATCATTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11535.41 Da        Isoelectric Point: 9.6206

>AT120686 WP_134358191.1 NZ_CP038033:2221774-2222076 [Nitrosococcus wardiae]
MFKNGMRPVHPGEILREDYLVPLEMSVNALAKALHVPTPRINEIVRERRGISADTALRLARYFDTTPQFWLGLQAEYDLR
VAEIKEAKRIISEIQPRHVA

Download         Length: 303 bp

>AT120686 NZ_CP038033:2221774-2222076 [Nitrosococcus wardiae]
ATGTTTAAAAATGGGATGCGCCCAGTTCATCCTGGAGAAATCTTGCGCGAGGACTATCTTGTGCCGCTTGAGATGAGCGT
TAACGCGTTAGCGAAAGCACTGCATGTGCCCACGCCACGCATTAATGAGATTGTGCGGGAGAGACGTGGGATTAGCGCGG
ATACCGCGTTGCGATTAGCCCGCTATTTTGACACCACCCCTCAATTCTGGCTGGGACTACAAGCCGAGTACGACCTGCGC
GTTGCTGAAATAAAAGAAGCCAAACGTATTATCAGCGAAATCCAGCCCCGGCATGTTGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References