Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1163768..1164379 Replicon chromosome
Accession NZ_CP038033
Organism Nitrosococcus wardiae strain D1FHS

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E3U44_RS05675 Protein ID WP_134357073.1
Coordinates 1163768..1164049 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag E3U44_RS05680 Protein ID WP_134357074.1
Coordinates 1164065..1164379 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3U44_RS05665 1160385..1161884 + 1500 WP_166804999.1 TIR domain-containing protein -
E3U44_RS05670 1162185..1163315 + 1131 WP_134357071.1 RelA/SpoT domain-containing protein -
E3U44_RS05675 1163768..1164049 + 282 WP_134357073.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3U44_RS05680 1164065..1164379 + 315 WP_134357074.1 HigA family addiction module antidote protein Antitoxin
E3U44_RS05685 1164607..1165644 - 1038 WP_134357075.1 helix-turn-helix domain-containing protein -
E3U44_RS05690 1166045..1166632 + 588 WP_134357077.1 OsmC family protein -
E3U44_RS05695 1166727..1167575 - 849 WP_134357078.1 conjugal transfer protein TraL -
E3U44_RS05700 1167587..1167952 - 366 WP_134357079.1 TraK family protein -
E3U44_RS05705 1168507..1169139 + 633 WP_166805000.1 FkbM family methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(10-102)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10532.05 Da        Isoelectric Point: 9.1961

>T120682 WP_134357073.1 NZ_CP038033:1163768-1164049 [Nitrosococcus wardiae]
MIKTFADKRTQELFCKGVSKKFPADAAPRAARKLEYVHLAEQLGDLKVPPGNRLHTLSGDRKGQHAISINAQWRICFRFE
NGDAYDVEVCGYH

Download         Length: 282 bp

>T120682 NZ_CP038033:1163768-1164049 [Nitrosococcus wardiae]
ATGATCAAGACCTTCGCAGATAAGCGCACCCAAGAGCTTTTTTGCAAAGGAGTTTCAAAGAAATTCCCTGCAGATGCTGC
TCCAAGGGCAGCCCGTAAACTTGAATATGTTCATTTGGCGGAACAACTGGGCGATTTGAAAGTTCCGCCTGGTAATCGGC
TTCACACGCTTTCTGGCGATCGGAAGGGGCAGCATGCCATATCAATCAATGCTCAATGGCGTATCTGCTTTCGTTTTGAA
AACGGTGACGCATACGATGTTGAAGTGTGCGGCTATCATTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11514.27 Da        Isoelectric Point: 8.6819

>AT120682 WP_134357074.1 NZ_CP038033:1164065-1164379 [Nitrosococcus wardiae]
MAIPNTTGMQRKPTHPGEMLREDFIPDYGLTVAGLAEALGVSRQSVNELLRERRAVSPEMALRLGRLFGNSPEFWLNAQR
AIDLWAAAKSVKDEIARIKPLDAA

Download         Length: 315 bp

>AT120682 NZ_CP038033:1164065-1164379 [Nitrosococcus wardiae]
ATGGCTATTCCCAACACTACTGGTATGCAACGCAAACCGACTCATCCGGGGGAAATGCTGCGGGAAGATTTTATTCCAGA
CTATGGGTTGACTGTAGCGGGTTTGGCCGAAGCGCTCGGTGTATCACGCCAGTCCGTCAATGAACTACTACGTGAACGGC
GGGCTGTCAGTCCGGAAATGGCCCTACGGCTTGGTCGTCTGTTTGGTAACTCTCCAGAGTTTTGGTTGAATGCGCAGCGC
GCAATCGATCTGTGGGCGGCAGCTAAGTCAGTTAAAGACGAGATTGCCCGAATCAAGCCATTGGACGCTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References