Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 24414..25065 Replicon plasmid pAR2
Accession NZ_CP038024
Organism Acinetobacter radioresistens strain DD78

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E3H47_RS14675 Protein ID WP_138001026.1
Coordinates 24414..24770 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E3H47_RS14680 Protein ID WP_001140620.1
Coordinates 24763..25065 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3H47_RS14645 19687..20349 + 663 WP_032028996.1 response regulator transcription factor -
E3H47_RS14650 20355..21725 + 1371 WP_032028997.1 sensor histidine kinase N-terminal domain-containing protein -
E3H47_RS14660 21951..23276 - 1326 WP_079281624.1 ISNCY family transposase -
E3H47_RS14670 23539..23766 + 228 WP_138001025.1 hypothetical protein -
E3H47_RS14675 24414..24770 + 357 WP_138001026.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E3H47_RS14680 24763..25065 + 303 WP_001140620.1 XRE family transcriptional regulator Antitoxin
E3H47_RS14685 25128..25769 - 642 WP_138001027.1 hypothetical protein -
E3H47_RS14690 25766..26875 - 1110 WP_138001028.1 hypothetical protein -
E3H47_RS14700 27249..27635 - 387 WP_138001030.1 hypothetical protein -
E3H47_RS14705 28064..29344 - 1281 WP_138001031.1 hypothetical protein -
E3H47_RS14710 29355..29636 - 282 WP_138001032.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..69207 69207
- flank IS/Tn - - 21951..23324 1373


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13615.61 Da        Isoelectric Point: 6.4659

>T120672 WP_138001026.1 NZ_CP038024:24414-24770 [Acinetobacter radioresistens]
MWTVITTDLFNEWLEQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYESKFTNMKELRVQHRGRPLRAFFAFDPLRQAI
ILCIADKGGKKRFYKDMLDIADEQYQLHLTTLGDKSNG

Download         Length: 357 bp

>T120672 NZ_CP038024:24414-24770 [Acinetobacter radioresistens]
ATGTGGACAGTCATTACGACAGATCTATTTAATGAATGGCTTGAACAGCAAGATGAATCGACACAAGAGAAAGTTTTAGC
TGCCCTGGTTGTTCTACAGCAGCAGGGACCGAGTTTAGGTCGCCCTTTAGTAGATACTGTGTATGAGTCTAAATTTACCA
ACATGAAAGAACTGCGCGTTCAACATCGCGGCAGACCATTGAGGGCCTTCTTCGCATTTGATCCCTTACGACAGGCTATT
ATTCTATGTATTGCTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGACATGCTGGATATTGCAGATGAGCAATACCAACT
TCATCTCACCACCCTAGGAGATAAATCTAATGGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11227.02 Da        Isoelectric Point: 6.4759

>AT120672 WP_001140620.1 NZ_CP038024:24763-25065 [Acinetobacter radioresistens]
MAKTLQELLASRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT120672 NZ_CP038024:24763-25065 [Acinetobacter radioresistens]
ATGGCTAAGACTCTACAAGAATTGTTAGCTAGCCGCTCTCCAGAGAGCCAAGCCCGTATTCAAAAAATGGCAGATGAATT
ACTGCTAGAAAATCAGCTTCATCTTATTCGTGAAGAACTCGAAATTTCTCAAAAAGAGCTTGCTGAAACTTTGGGAATAA
AACAGCCATCACTTTCAGCAATAGAAAATCGTGGCAATGATCTGAAGATATCAACCATGAAAAAGTATGTTGAAGCAATG
GGTGGGAAGCTTCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGTTTCAATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References