Detailed information of TA system TA120661

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2076704..2077003
• Replicon: chromosome
• Accession: NZ_CP038021
• Organism: Staphylococcus aureus strain 04-002

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: E3I93_RS10595
• Protein ID: WP_011447039.1
• Coordinates: 2076827..2077003 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2076704..2076761 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3I93_RS10545	2072081..2072341	+	261	WP_001791826.1	hypothetical protein	-
E3I93_RS10550	2072394..2072744	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
E3I93_RS10555	2073428..2073877	+	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
E3I93_RS10560	2073972..2074310	-	339	Protein_1957	SH3 domain-containing protein	-
E3I93_RS10575	2074912..2075403	-	492	WP_000920041.1	staphylokinase	-
E3I93_RS10580	2075594..2076349	-	756	WP_000861038.1	CHAP domain-containing protein	-
E3I93_RS10585	2076361..2076615	-	255	WP_000611512.1	phage holin	-
E3I93_RS10590	2076667..2076774	+	108	WP_031790389.1	hypothetical protein	-
-	2076696..2076835	+	140	NuclAT_0	-	-
-	2076696..2076835	+	140	NuclAT_0	-	-
-	2076696..2076835	+	140	NuclAT_0	-	-
-	2076696..2076835	+	140	NuclAT_0	-	-
-	2076704..2076761	+	58	-	-	Antitoxin
E3I93_RS10595	2076827..2077003	-	177	WP_011447039.1	putative holin-like toxin	Toxin
E3I93_RS10600	2077153..2077449	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
E3I93_RS10605	2077507..2077794	-	288	WP_001040254.1	hypothetical protein	-
E3I93_RS10610	2077841..2077993	-	153	WP_001153681.1	hypothetical protein	-
E3I93_RS10615	2077983..2081768	-	3786	WP_134521565.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / scn / chp / sak / hlb / tsst-1 / groEL	2066622..2138257	71635

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T120661 WP_011447039.1 NZ_CP038021:c2077003-2076827 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T120661 NZ_CP038021:c2077003-2076827 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT120661 NZ_CP038021:2076704-2076761 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• PDB: 7NS1

Antitoxin