Detailed information of TA system TA120655

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1583643..1584222
• Replicon: chromosome
• Accession: NZ_CP038021
• Organism: Staphylococcus aureus strain 04-002

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: E3I93_RS07850
• Protein ID: WP_001025401.1
• Coordinates: 1583977..1584222 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1583643..1584008 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3I93_RS07810	1580385..1580942	-	558	WP_000645048.1	DUF2815 family protein	-
E3I93_RS07815	1580968..1582134	-	1167	WP_134521535.1	DUF2800 domain-containing protein	-
E3I93_RS07820	1582131..1582493	-	363	WP_000279452.1	hypothetical protein	-
E3I93_RS07825	1582508..1582831	-	324	WP_000174996.1	hypothetical protein	-
E3I93_RS07830	1582911..1583072	-	162	WP_001285961.1	DUF1270 domain-containing protein	-
E3I93_RS07835	1583085..1583348	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
E3I93_RS07840	1583373..1583588	-	216	WP_001097552.1	hypothetical protein	-
E3I93_RS07845	1583643..1584008	+	366	WP_134521537.1	hypothetical protein	Antitoxin
E3I93_RS07850	1583977..1584222	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
E3I93_RS07855	1584289..1584669	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
E3I93_RS07865	1584922..1585134	+	213	WP_000362644.1	hypothetical protein	-
E3I93_RS14830	1585175..1585324	-	150	WP_000771849.1	hypothetical protein	-
E3I93_RS07870	1585339..1585782	-	444	WP_000435357.1	hypothetical protein	-
E3I93_RS07875	1585830..1586042	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
E3I93_RS07880	1586194..1586925	+	732	WP_000511090.1	XRE family transcriptional regulator	-
E3I93_RS07885	1586996..1587178	+	183	WP_000705240.1	hypothetical protein	-
E3I93_RS07890	1587215..1587361	+	147	WP_072403847.1	hypothetical protein	-
E3I93_RS07895	1587358..1587972	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1545080..1602076	56996

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T120655 WP_001025401.1 NZ_CP038021:c1584222-1583977 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T120655 NZ_CP038021:c1584222-1583977 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT120655 NZ_CP038021:1583643-1584008 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATAGCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin