Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1576598..1577021 Replicon chromosome
Accession NZ_CP038021
Organism Staphylococcus aureus strain 04-002

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag E3I93_RS07775 Protein ID WP_001065110.1
Coordinates 1576770..1577021 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag E3I93_RS07770 Protein ID WP_000028425.1
Coordinates 1576598..1576780 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E3I93_RS07730 1571993..1572283 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
E3I93_RS07735 1572417..1572521 + 105 WP_015978074.1 hypothetical protein -
E3I93_RS07740 1572636..1575071 - 2436 WP_134521533.1 virulence-associated E family protein -
E3I93_RS07745 1575123..1575323 - 201 WP_000265258.1 DUF1514 family protein -
E3I93_RS07750 1575391..1575543 - 153 WP_031875401.1 transcriptional regulator -
E3I93_RS07755 1575536..1575772 - 237 WP_000483477.1 hypothetical protein -
E3I93_RS07760 1575797..1576033 - 237 WP_000195806.1 DUF1381 domain-containing protein -
E3I93_RS07765 1576070..1576605 - 536 Protein_1458 dUTPase -
E3I93_RS07770 1576598..1576780 - 183 WP_000028425.1 hypothetical protein Antitoxin
E3I93_RS07775 1576770..1577021 - 252 WP_001065110.1 DUF1024 family protein Toxin
E3I93_RS07780 1577036..1577291 - 256 Protein_1461 hypothetical protein -
E3I93_RS07785 1577306..1577506 - 201 WP_000235324.1 hypothetical protein -
E3I93_RS07790 1577509..1577766 - 258 WP_000022730.1 DUF3310 domain-containing protein -
E3I93_RS07795 1577766..1578167 - 402 WP_000113974.1 PVL family protein -
E3I93_RS07800 1578167..1578352 - 186 WP_001164629.1 DUF3113 family protein -
E3I93_RS07805 1578365..1580317 - 1953 WP_001802096.1 DNA polymerase -
E3I93_RS07810 1580385..1580942 - 558 WP_000645048.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1545080..1602076 56996


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T120654 WP_001065110.1 NZ_CP038021:c1577021-1576770 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T120654 NZ_CP038021:c1577021-1576770 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCCGTTATCAGTGCTAGTGCGTATAACGGTAATGATACAGAGGGATTACTAAA
AGAGATTGAGGACGTATATAAGAAAGCGCGAGCGTTTGATGAAATACTTGAAGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT120654 WP_000028425.1 NZ_CP038021:c1576780-1576598 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT120654 NZ_CP038021:c1576780-1576598 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTACAAGTTATCTGACGGCTCTATTATCAGTCTCATAGACTTTGTTATTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References