Detailed information of TA system TA120653

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1001325..1001574
• Replicon: chromosome
• Accession: NZ_CP038021
• Organism: Staphylococcus aureus strain 04-002

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: E3I93_RS04945
• Protein ID: WP_000623369.1
• Coordinates: 1001325..1001432 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	1001427..1001574 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E3I93_RS04920	997998..998567	-	570	WP_000287265.1	competence protein ComK	-
E3I93_RS04925	998777..998995	+	219	WP_000876825.1	IDEAL domain-containing protein	-
E3I93_RS04930	999076..1000062	-	987	WP_000668820.1	lipoate--protein ligase	-
E3I93_RS04935	1000261..1000437	+	177	WP_000214898.1	YkvS family protein	-
E3I93_RS04940	1000452..1001054	+	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
E3I93_RS04945	1001325..1001432	+	108	WP_000623369.1	putative holin-like toxin	Toxin
-	1001427..1001574	-	148	-	-	Antitoxin
E3I93_RS04950	1001971..1002072	+	102	WP_001790623.1	hypothetical protein	-
E3I93_RS04955	1002082..1002354	+	273	WP_001794574.1	lactococcin 972 family bacteriocin	-
E3I93_RS04960	1002398..1004362	+	1965	WP_000870819.1	bacteriocin-associated integral membrane family protein	-
E3I93_RS04965	1004365..1004685	+	321	WP_000873929.1	YxeA family protein	-
E3I93_RS04970	1004682..1005323	+	642	WP_134521470.1	ABC transporter ATP-binding protein	-
E3I93_RS04975	1005411..1005701	-	291	WP_001791476.1	hypothetical protein	-
E3I93_RS04980	1006042..1006329	+	288	WP_000410718.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T120653 WP_000623369.1 NZ_CP038021:1001325-1001432 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

>T120653 NZ_CP038021:1001325-1001432 [Staphylococcus aureus]
GTGATATCTATTGCAAACGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 148 bp

>AT120653 NZ_CP038021:c1001574-1001427 [Staphylococcus aureus]
CAATTAAATAAAAGATATGTTACTATAAAAATGTAAAAAGACGACATGCAGGAACATGTCGCCTAATGAGCCCGTTAAAA
AGACGGTGACTAAATGAGATTTTCTTTAACCATCATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Structures

Antitoxin