Detailed information of TA system TA120600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2846788..2847565
• Replicon: chromosome
• Accession: NZ_CP037993
• Organism: Herbaspirillum huttiense strain NFYY 53159

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: E2K99_RS12865
• Protein ID: WP_134222455.1
• Coordinates: 2846788..2847084 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: E2K99_RS12870
• Protein ID: WP_134222456.1
• Coordinates: 2847086..2847565 (+)
• Length: 160 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2K99_RS12840	2841933..2843012	+	1080	WP_134222451.1	adenosine deaminase	-
E2K99_RS12845	2843025..2844746	-	1722	WP_134222452.1	HAMP domain-containing protein	-
E2K99_RS12850	2844739..2844957	+	219	WP_134222453.1	hypothetical protein	-
E2K99_RS12855	2845071..2846336	+	1266	WP_134222454.1	multidrug effflux MFS transporter	-
E2K99_RS12860	2846403..2846606	+	204	WP_039785818.1	hypothetical protein	-
E2K99_RS12865	2846788..2847084	+	297	WP_134222455.1	type II toxin-antitoxin system MqsR family toxin	Toxin
E2K99_RS12870	2847086..2847565	+	480	WP_134222456.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
E2K99_RS12875	2847640..2850012	-	2373	WP_134224101.1	DNA polymerase II	-
E2K99_RS12880	2850208..2851071	+	864	WP_134222457.1	hypothetical protein	-
E2K99_RS12885	2851212..2851418	+	207	WP_166675067.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (6-97)

Antitoxin

• Zinc finger, MqsA-type (3-46)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10820.52 Da
• Isoelectric Point: 7.4212

>T120600 WP_134222455.1 NZ_CP037993:2846788-2847084 [Herbaspirillum huttiense]
MEKNSPHCPLSTVRDLIRQQRVAATHTAKAGAAAVGLSFLDMLDVVMALTDGDFHKAMTTHADDNVWQDVYKPLTHVGQL
YVKLTVVNSLLIVSFKEK

Nucleotide

• Length: 297 bp

>T120600 NZ_CP037993:2846788-2847084 [Herbaspirillum huttiense]
ATGGAAAAGAATTCGCCTCACTGCCCGCTCTCGACAGTCCGTGACTTGATCAGACAGCAGCGCGTCGCTGCCACCCATAC
GGCGAAAGCGGGCGCGGCGGCTGTCGGGCTGAGCTTTCTCGACATGCTTGATGTGGTGATGGCGCTGACCGATGGCGATT
TCCACAAAGCCATGACCACCCATGCGGATGACAACGTTTGGCAGGACGTCTACAAGCCACTGACCCACGTAGGCCAGCTT
TACGTGAAGCTGACCGTGGTGAATTCCCTGCTGATTGTTTCCTTCAAGGAGAAATGA

Antitoxin

Protein

• Length: 160 a.a.
• Molecular weight: 17193.55 Da
• Isoelectric Point: 7.0849

>AT120600 WP_134222456.1 NZ_CP037993:2847086-2847565 [Herbaspirillum huttiense]
MKCPTCGAAEMVHDTRDLPYTYKGESTTIAAVTADFCPACGESITDFAESSRVSAEMLAFNREVNATRIEPAEIAETRAA
LKLSQRDASVLFGGGINAFNRYEAGSTRPPLSLVQLLRLLRNHPELLEEVRTNSPATAQAQPLGMKQPTGKSLPAALRR

Nucleotide

• Length: 480 bp

>AT120600 NZ_CP037993:2847086-2847565 [Herbaspirillum huttiense]
ATGAAATGCCCCACCTGCGGTGCCGCTGAAATGGTGCATGACACCCGCGACCTGCCCTATACCTACAAGGGTGAGAGCAC
GACCATCGCGGCAGTGACCGCTGATTTCTGCCCGGCCTGTGGCGAGTCCATCACCGACTTCGCCGAGTCATCCCGTGTCT
CTGCCGAAATGCTGGCCTTCAACCGGGAGGTGAACGCCACCCGCATCGAACCGGCGGAGATCGCGGAGACCCGTGCGGCG
CTGAAGCTTAGCCAGCGCGATGCCAGCGTTCTGTTCGGCGGGGGCATCAACGCGTTCAACCGCTATGAGGCGGGTTCGAC
GAGACCGCCCCTGTCGCTGGTGCAGCTCTTGCGCCTGTTGCGCAATCACCCTGAGTTGCTTGAAGAGGTAAGGACGAATT
CTCCAGCCACCGCCCAAGCCCAGCCTTTGGGCATGAAACAGCCCACGGGCAAATCGCTCCCGGCGGCACTGCGGCGCTGA