Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2457996..2458604 Replicon chromosome
Accession NZ_CP037993
Organism Herbaspirillum huttiense strain NFYY 53159

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag E2K99_RS11180 Protein ID WP_134222247.1
Coordinates 2458317..2458604 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E2K99_RS11175 Protein ID WP_134222246.1
Coordinates 2457996..2458307 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2K99_RS11160 2453890..2455089 + 1200 WP_134222245.1 HDOD domain-containing protein -
E2K99_RS11165 2455095..2457167 + 2073 WP_134224079.1 EAL domain-containing protein -
E2K99_RS11170 2457427..2457963 + 537 WP_034335522.1 superoxide dismutase family protein -
E2K99_RS11175 2457996..2458307 - 312 WP_134222246.1 HigA family addiction module antidote protein Antitoxin
E2K99_RS11180 2458317..2458604 - 288 WP_134222247.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E2K99_RS11190 2459064..2460317 - 1254 WP_006462578.1 aspartate kinase -
E2K99_RS11195 2460847..2461125 - 279 WP_034329281.1 DUF4148 domain-containing protein -
E2K99_RS11200 2461376..2462287 + 912 WP_039788330.1 LysR family transcriptional regulator -
E2K99_RS11205 2462325..2462753 - 429 WP_034329278.1 thioredoxin family protein -
E2K99_RS11210 2462865..2463584 + 720 WP_134222248.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(23-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-100)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10734.34 Da        Isoelectric Point: 8.8052

>T120598 WP_134222247.1 NZ_CP037993:c2458604-2458317 [Herbaspirillum huttiense]
MILSFRCADTEALFHGKSVPRFANIRAAAERKLQMLDAAATLEFLRTPPGNRLESLHGNRDGQHSIRINSQFRLCFMCHS
IGRIGASHVEIIDYH

Download         Length: 288 bp

>T120598 NZ_CP037993:c2458604-2458317 [Herbaspirillum huttiense]
ATGATACTCAGCTTCCGATGCGCAGATACCGAAGCCTTATTTCACGGAAAGTCGGTGCCTCGCTTTGCCAACATCCGTGC
TGCGGCCGAACGCAAGCTGCAGATGCTGGATGCAGCTGCTACGCTGGAATTCCTGCGTACGCCGCCAGGCAACCGCCTAG
AGTCACTTCACGGCAACCGGGACGGCCAGCACAGCATCCGCATCAACAGCCAATTCCGGCTTTGCTTCATGTGCCACAGC
ATCGGACGCATCGGAGCATCCCACGTTGAAATCATCGATTACCACTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11541.20 Da        Isoelectric Point: 8.8105

>AT120598 WP_134222246.1 NZ_CP037993:c2458307-2457996 [Herbaspirillum huttiense]
MSSPGNRMRPIHPGEILREEFLAPINLSANALAIALHVPATRIGEIVNERRGISPDTALRLARFFGGDAQSWLNLQMTYD
LKIAQRDHGARIEQEVRPLERTS

Download         Length: 312 bp

>AT120598 NZ_CP037993:c2458307-2457996 [Herbaspirillum huttiense]
ATGAGCTCTCCCGGCAATCGCATGCGCCCGATTCATCCTGGCGAGATCCTGCGTGAGGAATTCCTCGCACCGATCAACCT
GAGCGCCAACGCTTTGGCCATCGCCCTGCACGTCCCGGCCACGCGCATCGGAGAGATCGTCAACGAGCGGCGCGGCATCT
CCCCAGATACCGCCCTGCGACTGGCACGCTTTTTCGGTGGCGATGCGCAGTCCTGGCTGAACCTGCAAATGACCTACGAT
CTCAAGATCGCCCAGCGTGACCATGGCGCGCGGATCGAACAGGAAGTGCGCCCGCTGGAACGCACTTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References