Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1201758..1202517 Replicon chromosome
Accession NZ_CP037952
Organism Parashewanella spongiae strain HJ039

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E2I05_RS04420 Protein ID WP_121855262.1
Coordinates 1201758..1202078 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E2I05_RS04425 Protein ID WP_121855261.1
Coordinates 1202101..1202517 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2I05_RS04395 1198416..1198652 - 237 Protein_868 Fic family protein -
E2I05_RS04400 1198985..1199251 + 267 WP_121855322.1 DUF1778 domain-containing protein -
E2I05_RS04405 1199252..1199344 + 93 Protein_870 GNAT family N-acetyltransferase -
E2I05_RS04410 1199422..1200983 + 1562 WP_133309487.1 IS3 family transposase -
E2I05_RS04415 1200989..1201468 + 480 WP_121855263.1 GNAT family N-acetyltransferase -
E2I05_RS04420 1201758..1202078 + 321 WP_121855262.1 type II toxin-antitoxin system HigB family toxin Toxin
E2I05_RS04425 1202101..1202517 + 417 WP_121855261.1 transcriptional regulator Antitoxin
E2I05_RS04430 1202781..1203302 + 522 WP_121855260.1 plasmid mobilization relaxosome protein MobC -
E2I05_RS04435 1203295..1203831 + 537 WP_121855259.1 relaxase/mobilization nuclease domain-containing protein -
E2I05_RS04440 1203941..1205410 + 1470 WP_133309488.1 ISKra4 family transposase -
E2I05_RS04445 1205421..1205987 - 567 WP_121855306.1 hypothetical protein -
E2I05_RS04450 1206137..1206511 - 375 WP_121855305.1 PIN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-95)

Antitoxin

Antitoxin HigA

(3-138)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12520.66 Da        Isoelectric Point: 10.0198

>T120549 WP_121855262.1 NZ_CP037952:1201758-1202078 [Parashewanella spongiae]
MHVVKKEAFETAKILHPKYAKAIDDTYKVLDKSKPKNPDELKKLFPSLDNFKYVDKWYVIDIGGKKLRLIAFITFLGDGH
FYVRHICTHAEYDKIVDEYRTKSKKK

Download         Length: 321 bp

>T120549 NZ_CP037952:1201758-1202078 [Parashewanella spongiae]
ATGCACGTCGTAAAAAAAGAAGCTTTTGAAACAGCAAAAATTCTGCATCCGAAATATGCAAAAGCTATTGATGATACATA
TAAGGTACTGGATAAAAGTAAGCCCAAAAACCCAGATGAACTAAAAAAGTTATTCCCGAGTCTCGATAACTTTAAGTATG
TAGATAAATGGTATGTGATAGACATTGGTGGAAAAAAACTCAGATTAATTGCTTTTATTACTTTTTTAGGTGATGGGCAC
TTCTATGTTAGGCATATTTGTACTCATGCCGAATACGACAAAATTGTTGATGAATACAGAACAAAAAGCAAAAAGAAGTA
A

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15822.19 Da        Isoelectric Point: 4.4345

>AT120549 WP_121855261.1 NZ_CP037952:1202101-1202517 [Parashewanella spongiae]
MNLHEMVTAANNAFIALPWIAGIQSRDQYDELMELADELVEDYEKNHTLIELLLPVIHKYEEEADEFKEFKKDIDAIDPA
IAMLRVIIDQHQLTYSDFKNEIGGKSLVSMILNGERSLTLSHIKALSLRFGIDKAMFI

Download         Length: 417 bp

>AT120549 NZ_CP037952:1202101-1202517 [Parashewanella spongiae]
ATGAACTTACATGAAATGGTAACAGCTGCTAATAACGCTTTCATAGCGTTACCTTGGATTGCAGGGATTCAAAGCCGAGA
TCAATATGACGAGCTAATGGAGCTTGCTGATGAACTTGTAGAAGACTATGAAAAAAATCATACCTTGATTGAGCTATTGC
TCCCTGTTATTCATAAGTACGAAGAAGAAGCTGACGAATTTAAAGAGTTTAAAAAAGATATCGACGCCATTGACCCAGCC
ATCGCTATGTTGAGAGTCATTATCGATCAACATCAATTAACTTATAGCGACTTTAAAAATGAAATTGGGGGAAAGTCTCT
CGTATCTATGATACTAAATGGTGAGCGCTCATTAACGCTTAGCCATATTAAAGCCTTATCTTTACGATTTGGAATCGATA
AGGCGATGTTTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References