Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 356711..357438 Replicon chromosome
Accession NZ_CP037923
Organism Shigella flexneri 5a str. M90T

Toxin (Protein)


Gene name higB Uniprot ID A0A4P7TJ48
Locus tag EKN05_RS01780 Protein ID WP_000547561.1
Coordinates 357127..357438 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EKN05_RS01775 Protein ID WP_000126296.1
Coordinates 356711..357130 (-) Length 140 a.a.

Genomic Context

EKN05_RS01765EKN05_RS01770EKN05_RS01755EKN05_RS01760EKN05_RS01775EKN05_RS01780EKN05_RS01785EKN05_RS01790EKN05_RS01795EKN05_RS01800EKN05_RS01805EKN05_RS01810
Location: 353697..355163 (1467 bp)
Type: Others
Protein ID: WP_136350408.1
Location: 355172..356596 (1425 bp)
Type: Others
Protein ID: WP_005105741.1
Location: 351760..352287 (528 bp)
Type: Others
Protein ID: WP_001078777.1
Location: 352437..353447 (1011 bp)
Type: Others
Protein ID: WP_005051459.1
Location: 356711..357130 (420 bp)
Type: Antitoxin
Protein ID: WP_000126296.1
Location: 357127..357438 (312 bp)
Type: Toxin
Protein ID: WP_000547561.1
Location: 357611..358354 (744 bp)
Type: Others
Protein ID: WP_044024082.1
Location: 358397..358867 (471 bp)
Type: Others
Protein ID: WP_000132961.1
Location: 358860..359270 (411 bp)
Type: Others
Protein ID: WP_001291916.1
Location: 359267..360034 (768 bp)
Type: Others
Protein ID: WP_000067379.1
Location: 360034..360576 (543 bp)
Type: Others
Protein ID: WP_000493785.1
Location: 360586..362295 (1710 bp)
Type: Others
Protein ID: WP_005063855.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EKN05_RS01755 (EKN05_001765)351760..352287-528WP_001078777.1electron transport protein HydN-
EKN05_RS01760 (EKN05_001770)352437..353447-1011WP_005051459.1DNA-binding transcriptional regulator AscG-
EKN05_RS01765 (EKN05_001775)353697..355163+1467WP_136350408.1PTS cellobiose/arbutin/salicin transporter subunit IIBC-
EKN05_RS01770 (EKN05_001780)355172..356596+1425WP_005105741.16-phospho-beta-glucosidase AscB-
EKN05_RS01775 (EKN05_001785)356711..357130-420WP_000126296.1helix-turn-helix domain-containing proteinAntitoxin
EKN05_RS01780 (EKN05_001790)357127..357438-312WP_000547561.1type II toxin-antitoxin system HigB family toxinToxin
EKN05_RS01785 (EKN05_001795)357611..358354-744WP_044024082.1hypothetical protein-
EKN05_RS01790 (EKN05_001800)358397..358867-471WP_000132961.1hydrogenase maturation peptidase HycI-
EKN05_RS01795 (EKN05_001805)358860..359270-411WP_001291916.1formate hydrogenlyase assembly protein HycH-
EKN05_RS01800 (EKN05_001810)359267..360034-768WP_000067379.1formate hydrogenlyase subunit HycG-
EKN05_RS01805 (EKN05_001815)360034..360576-543WP_000493785.1formate hydrogenlyase subunit HycF-
EKN05_RS01810 (EKN05_001820)360586..362295-1710WP_005063855.1formate hydrogenlyase subunit HycE-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12370.06 Da        Isoelectric Point: 9.7105

>T120360 WP_000547561.1 NZ_CP037923:c357438-357127 [Shigella flexneri 5a str. M90T]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDAGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

>T120360 NZ_CP037923:c357438-357127 [Shigella flexneri 5a str. M90T]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAGATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGCAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.38 Da        Isoelectric Point: 4.3653

>AT120360 WP_000126296.1 NZ_CP037923:c357130-356711 [Shigella flexneri 5a str. M90T]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNQEFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT120360 NZ_CP037923:c357130-356711 [Shigella flexneri 5a str. M90T]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACCAAGAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGCGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A4P7TJ48

Antitoxin

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Source
ID
Structure
No matching records found

References