Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4094131..4094389 Replicon chromosome
Accession NZ_CP037903
Organism Escherichia coli strain LHM10-1

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag E1J55_RS19910 Protein ID WP_000809168.1
Coordinates 4094237..4094389 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4094131..4094188 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1J55_RS19895 4090097..4091590 - 1494 WP_001173014.1 sulfatase-like hydrolase/transferase -
E1J55_RS19900 4091610..4092371 - 762 WP_136698536.1 hypothetical protein -
- 4094131..4094188 - 58 - - Antitoxin
E1J55_RS19910 4094237..4094389 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
E1J55_RS19915 4094467..4095579 + 1113 WP_001300563.1 IS4-like element IS421 family transposase -
E1J55_RS19920 4095842..4096972 - 1131 WP_136698537.1 molecular chaperone DnaJ -
E1J55_RS19925 4097061..4098977 - 1917 WP_000516135.1 molecular chaperone DnaK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4081602..4095742 14140
- inside IScluster/Tn - - 4092822..4095742 2920


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T120293 WP_000809168.1 NZ_CP037903:4094237-4094389 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T120293 NZ_CP037903:4094237-4094389 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT120293 NZ_CP037903:c4094188-4094131 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References