Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1850758..1851260 Replicon chromosome
Accession NZ_CP037903
Organism Escherichia coli strain LHM10-1

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag E1J55_RS08780 Protein ID WP_000767835.1
Coordinates 1851006..1851260 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag E1J55_RS08775 Protein ID WP_001259255.1
Coordinates 1850758..1851009 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1J55_RS08750 1845935..1847002 - 1068 WP_000080072.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
E1J55_RS08755 1847002..1848072 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
E1J55_RS08760 1848069..1849373 - 1305 WP_001413482.1 histidinol dehydrogenase -
E1J55_RS08765 1849379..1850278 - 900 WP_000131774.1 ATP phosphoribosyltransferase -
E1J55_RS08770 1850424..1850474 - 51 WP_001364200.1 his operon leader peptide -
E1J55_RS08775 1850758..1851009 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
E1J55_RS08780 1851006..1851260 + 255 WP_000767835.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
E1J55_RS08785 1851343..1852167 + 825 WP_000754737.1 SDR family oxidoreductase -
E1J55_RS08790 1852213..1853142 + 930 WP_000803351.1 LysR family transcriptional regulator -
E1J55_RS08795 1853357..1853419 + 63 WP_010723108.1 membrane protein YoeI -
E1J55_RS08800 1853409..1854767 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
E1J55_RS08805 1854946..1856004 + 1059 WP_000492321.1 transport protein YeeE -
E1J55_RS08810 1856018..1856245 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10169.51 Da        Isoelectric Point: 7.2751

>T120278 WP_000767835.1 NZ_CP037903:1851006-1851260 [Escherichia coli]
VKLIWSEESWDDYLYWQETDNRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T120278 NZ_CP037903:1851006-1851260 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAATCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT120278 WP_001259255.1 NZ_CP037903:1850758-1851009 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT120278 NZ_CP037903:1850758-1851009 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References