Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 740610..741303 Replicon chromosome
Accession NZ_CP037903
Organism Escherichia coli strain LHM10-1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag E1J55_RS03620 Protein ID WP_000415584.1
Coordinates 740610..740906 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag E1J55_RS03625 Protein ID WP_000650107.1
Coordinates 740908..741303 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1J55_RS03585 735698..736012 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
E1J55_RS03590 736043..736624 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
E1J55_RS03595 736943..737275 + 333 WP_000917684.1 DUF2645 family protein -
E1J55_RS03600 737321..738670 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
E1J55_RS03605 738667..739326 - 660 WP_001221493.1 two-component system response regulator QseB -
E1J55_RS03610 739478..739870 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
E1J55_RS03615 739923..740405 + 483 WP_000183505.1 transcriptional regulator -
E1J55_RS03620 740610..740906 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
E1J55_RS03625 740908..741303 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
E1J55_RS03630 741491..742188 + 698 Protein_712 IS1 family transposase -
E1J55_RS03635 742213..743820 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
E1J55_RS03640 743958..746216 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 741895..742188 293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T120275 WP_000415584.1 NZ_CP037903:740610-740906 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T120275 NZ_CP037903:740610-740906 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT120275 WP_000650107.1 NZ_CP037903:740908-741303 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT120275 NZ_CP037903:740908-741303 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCTTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References