Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 423959..424629 Replicon chromosome
Accession NZ_CP037864
Organism Citrobacter sp. LY-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E1B03_RS02965 Protein ID WP_133085664.1
Coordinates 423959..424261 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E1B03_RS02970 Protein ID WP_103771872.1
Coordinates 424288..424629 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1B03_RS02945 419502..421025 - 1524 WP_003844755.1 sugar ABC transporter ATP-binding protein -
E1B03_RS02955 421140..423404 + 2265 WP_133085663.1 hybrid sensor histidine kinase/response regulator -
E1B03_RS02960 423474..423803 + 330 WP_003031807.1 hypothetical protein -
E1B03_RS02965 423959..424261 + 303 WP_133085664.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E1B03_RS02970 424288..424629 + 342 WP_103771872.1 HigA family addiction module antidote protein Antitoxin
E1B03_RS02975 424682..425440 - 759 WP_133085665.1 phosphonate metabolism protein PhnP -
E1B03_RS02980 425449..425883 - 435 WP_003031809.1 aminoalkylphosphonate N-acetyltransferase -
E1B03_RS02985 425870..426424 - 555 WP_103771874.1 ribose 1,5-bisphosphokinase -
E1B03_RS02990 426427..427563 - 1137 WP_103771875.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
E1B03_RS02995 427560..428246 - 687 WP_103771876.1 phosphonate C-P lyase system protein PhnL -
E1B03_RS03000 428489..429247 - 759 WP_103771877.1 phosphonate C-P lyase system protein PhnK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(6-99)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11870.52 Da        Isoelectric Point: 9.9581

>T120249 WP_133085664.1 NZ_CP037864:423959-424261 [Citrobacter sp. LY-1]
MSKSLNIRNFRDTWLEDFFERATPHRKIPADIHTALARKLDIINAAVSHRDLRSPPGNRYEELTGKLQEYSSIRVNKQYR
LIFKWINGKAEDVYLDPHIY

Download         Length: 303 bp

>T120249 NZ_CP037864:423959-424261 [Citrobacter sp. LY-1]
ATGTCTAAATCATTAAATATCAGAAATTTTCGGGATACATGGCTTGAAGATTTTTTTGAACGGGCGACACCGCACAGAAA
AATACCCGCGGATATTCACACTGCATTAGCCAGAAAGCTAGATATCATTAATGCGGCTGTTTCGCATCGGGATTTGCGCT
CGCCACCCGGTAACAGATATGAAGAGTTAACTGGAAAATTACAGGAATATTCTTCAATCAGAGTAAACAAGCAGTACCGA
TTAATATTTAAATGGATTAACGGTAAGGCCGAAGATGTGTACTTAGATCCACACATCTACTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 13059.88 Da        Isoelectric Point: 6.4763

>AT120249 WP_103771872.1 NZ_CP037864:424288-424629 [Citrobacter sp. LY-1]
MKQATRKPTTVGDILQYEYLEPLELKINDLAEILHVHRNTVSALVNNNRKLTTDMAFRLAKAFDTSVDFWRNLQAAVDLW
EVENDMRAQEELNRIVSVKDFIAQRNGESKKVA

Download         Length: 342 bp

>AT120249 NZ_CP037864:424288-424629 [Citrobacter sp. LY-1]
ATGAAACAGGCAACCAGAAAACCAACGACTGTGGGTGATATCCTGCAATATGAATACCTGGAGCCGCTCGAGCTGAAAAT
TAATGATCTGGCTGAAATACTGCATGTTCATCGCAATACGGTGAGCGCACTGGTCAACAATAATCGCAAATTAACAACGG
ATATGGCGTTTCGTTTGGCCAAAGCGTTCGATACTTCCGTTGATTTCTGGCGTAACTTACAGGCGGCGGTTGACCTGTGG
GAAGTTGAAAATGACATGCGGGCGCAAGAAGAACTGAACCGCATTGTTTCGGTTAAAGATTTTATTGCTCAGCGAAATGG
CGAGTCTAAAAAAGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References