Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 553489..554095 Replicon chromosome
Accession NZ_CP037745
Organism Rheinheimera sp. D18

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E0Z06_RS02650 Protein ID WP_207903173.1
Coordinates 553778..554095 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E0Z06_RS02645 Protein ID WP_132581636.1
Coordinates 553489..553776 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0Z06_RS02625 548564..549172 - 609 WP_132581628.1 dephospho-CoA kinase -
E0Z06_RS02630 549189..550067 - 879 WP_132581630.1 A24 family peptidase -
E0Z06_RS02635 550067..551296 - 1230 WP_132581632.1 type II secretion system F family protein -
E0Z06_RS02640 551377..553068 - 1692 WP_132581634.1 type IV-A pilus assembly ATPase PilB -
E0Z06_RS02645 553489..553776 - 288 WP_132581636.1 helix-turn-helix domain-containing protein Antitoxin
E0Z06_RS02650 553778..554095 - 318 WP_207903173.1 addiction module toxin RelE Toxin
E0Z06_RS02655 554401..554778 - 378 WP_132586653.1 pilin -
E0Z06_RS02660 554853..555269 - 417 WP_132586654.1 pilin -
E0Z06_RS02665 555660..556328 - 669 WP_132581638.1 cold shock domain-containing protein -
E0Z06_RS02670 556442..557311 - 870 WP_132581640.1 carboxylating nicotinate-nucleotide diphosphorylase -
E0Z06_RS02675 557314..557835 - 522 WP_132581642.1 TIGR02281 family clan AA aspartic protease -
E0Z06_RS02680 557904..558473 + 570 WP_132581644.1 1,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(44-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-87)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12227.28 Da        Isoelectric Point: 10.3340

>T120003 WP_207903173.1 NZ_CP037745:c554095-553778 [Rheinheimera sp. D18]
MFVIFVETTIFTKHLKALIPDDEYRKFQQFLVNQPEAGKVIKGSGGLRKVRWGSESQGKSGGVRVIYYYVQPNSHIRLLL
IYPKSEQTTLTDKQLKLLKDIIERW

Download         Length: 318 bp

>T120003 NZ_CP037745:c554095-553778 [Rheinheimera sp. D18]
ATGTTTGTGATATTTGTTGAAACAACCATTTTCACCAAACACCTTAAAGCCTTGATACCTGACGATGAATATCGTAAATT
TCAACAATTTTTGGTAAATCAGCCAGAAGCTGGAAAAGTAATAAAAGGCAGCGGAGGTTTACGTAAAGTTCGCTGGGGCT
CTGAAAGTCAGGGCAAAAGCGGTGGAGTCCGAGTAATTTACTATTACGTACAGCCCAACAGTCATATACGACTATTGTTA
ATATACCCAAAGAGCGAACAAACTACTTTAACCGATAAACAGCTGAAATTATTAAAAGATATAATCGAGAGGTGGTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10867.43 Da        Isoelectric Point: 6.9835

>AT120003 WP_132581636.1 NZ_CP037745:c553776-553489 [Rheinheimera sp. D18]
MNDNLFNELLESVQQMDEIVRGERQPCRETFIAAIKVKEIRQRTNLSQAAFADLIDVQLGTLRNWEQGRREPTGPAKALL
RAIERDPKHVLAALN

Download         Length: 288 bp

>AT120003 NZ_CP037745:c553776-553489 [Rheinheimera sp. D18]
ATGAACGACAACTTGTTTAATGAGCTTCTAGAAAGTGTGCAGCAAATGGATGAAATTGTTCGTGGTGAACGCCAGCCTTG
TCGTGAAACCTTTATTGCCGCTATTAAAGTTAAAGAAATACGTCAGCGTACGAATCTAAGTCAAGCTGCTTTTGCTGACC
TAATTGATGTTCAGTTGGGTACTTTACGTAATTGGGAACAAGGCCGTAGAGAACCAACCGGCCCAGCAAAAGCATTGTTG
CGAGCCATTGAGCGTGACCCTAAACATGTACTTGCAGCACTCAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References