119947

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/-
Location 2708796..2709459 Replicon chromosome
Accession NZ_CP036546
Organism Bacteroides fragilis strain DCMSKEJBY0001B

Toxin (Protein)


Gene name HipT Uniprot ID A0A4Q0U3J6
Locus tag EC80_RS11620 Protein ID WP_032536341.1
Coordinates 2709124..2709459 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A4Q0U0V4
Locus tag EC80_RS11615 Protein ID WP_032536342.1
Coordinates 2708796..2709122 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EC80_RS11585 2703958..2705001 + 1044 WP_032536360.1 glycosyltransferase family 4 protein -
EC80_RS11590 2705014..2705838 + 825 WP_022011505.1 glycosyltransferase family 2 protein -
EC80_RS11595 2705847..2706743 + 897 WP_032536359.1 NAD-dependent epimerase/dehydratase family protein -
EC80_RS11600 2706859..2707809 + 951 WP_032536345.1 glycosyltransferase family 4 protein -
EC80_RS11605 2707812..2708399 + 588 WP_032536344.1 N-acetylmuramidase family protein -
EC80_RS11610 2708584..2708799 + 216 WP_032536343.1 helix-turn-helix transcriptional regulator -
EC80_RS11615 2708796..2709122 + 327 WP_032536342.1 HipA N-terminal domain-containing protein Antitoxin
EC80_RS11620 2709124..2709459 + 336 WP_032536341.1 HipA domain-containing protein Toxin
EC80_RS11625 2709507..2711081 - 1575 WP_032531836.1 Rne/Rng family ribonuclease -
EC80_RS11630 2711361..2711636 - 276 WP_005776335.1 integration host factor subunit beta -
EC80_RS11635 2711841..2712887 + 1047 WP_032536340.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(1-82)

Antitoxin

HipA, N-terminal subdomain 1

(3-97)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13038.10 Da        Isoelectric Point: 9.2916

>T119947 WP_032536341.1 NZ_CP036546:2709124-2709459 [Bacteroides fragilis]
MHLKNFSLYSTKPISYVLTPAYDLLSTKLVLPADSEELALTLNGKKKKIKKSDFVVAMNSTGLEDKIIENVFNKFDHLQS
KWEEFIDVSFIQETTKERYKELIHENWKRIK

Download         Length: 336 bp

>T119947 NZ_CP036546:2709124-2709459 [Bacteroides fragilis]
ATGCATTTGAAGAACTTTTCTTTATATAGTACGAAACCTATTAGTTATGTTCTGACACCCGCTTATGACTTACTGTCAAC
GAAGTTAGTCCTTCCTGCCGATTCTGAGGAATTGGCATTAACACTTAATGGGAAGAAGAAGAAAATAAAGAAGTCGGACT
TTGTTGTTGCAATGAACTCGACCGGCTTGGAAGATAAGATTATTGAAAATGTTTTTAATAAGTTTGATCACCTTCAGTCT
AAATGGGAAGAGTTTATAGATGTTTCTTTTATACAAGAAACAACCAAAGAAAGGTATAAGGAGCTTATACATGAAAATTG
GAAAAGGATTAAGTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12203.00 Da        Isoelectric Point: 4.4217

>AT119947 WP_032536342.1 NZ_CP036546:2708796-2709122 [Bacteroides fragilis]
MKKAEIYVSNQLAGILIEDENGFSFTYTDEYISKGNRRPVSLTLPITHVPYTSSVLFPFFNGLIPEGWLLDIAEQSWKIS
SRDRMALLLACCKDCIGDSTLLLDYGEF

Download         Length: 327 bp

>AT119947 NZ_CP036546:2708796-2709122 [Bacteroides fragilis]
ATGAAAAAGGCTGAAATTTATGTTAGCAATCAGTTAGCCGGTATTTTGATTGAAGATGAAAATGGCTTTTCTTTCACTTA
TACAGACGAATATATTTCAAAGGGAAACCGACGACCTGTTAGTCTGACGCTTCCGATAACTCATGTCCCTTATACAAGCT
CTGTGCTGTTTCCTTTTTTTAATGGATTAATTCCTGAAGGATGGTTGCTTGATATTGCGGAACAAAGTTGGAAGATAAGT
AGTCGGGATAGAATGGCTTTGCTGCTGGCTTGTTGTAAGGATTGCATAGGAGATAGTACTCTTCTCTTGGATTACGGGGA
ATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q0U3J6

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q0U0V4

References