Detailed information of TA system TA119946

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/-
• Location: 2795546..2796209
• Replicon: chromosome
• Accession: NZ_CP036539
• Organism: Bacteroides fragilis strain DCMOUH0017B

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: EC81_RS12120
• Protein ID: WP_032543806.1
• Coordinates: 2795874..2796209 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: -
• Locus tag: EC81_RS12115
• Protein ID: WP_032543807.1
• Coordinates: 2795546..2795872 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EC81_RS12085	2790809..2791888	+	1080	WP_080720319.1	glycosyltransferase family 4 protein	-
EC81_RS12090	2791885..2792649	+	765	WP_032543811.1	glycosyltransferase	-
EC81_RS12095	2792646..2793608	+	963	WP_032543810.1	NAD-dependent epimerase/dehydratase family protein	-
EC81_RS12100	2793612..2794562	+	951	WP_032543809.1	glycosyltransferase family 4 protein	-
EC81_RS12105	2794562..2795149	+	588	WP_137569233.1	N-acetylmuramidase family protein	-
EC81_RS12110	2795334..2795549	+	216	WP_032536343.1	helix-turn-helix transcriptional regulator	-
EC81_RS12115	2795546..2795872	+	327	WP_032543807.1	HipA N-terminal domain-containing protein	Antitoxin
EC81_RS12120	2795874..2796209	+	336	WP_032543806.1	HipA domain-containing protein	Toxin
EC81_RS12125	2796257..2797831	-	1575	WP_032531836.1	Rne/Rng family ribonuclease	-
EC81_RS12130	2798111..2798386	-	276	WP_005776335.1	integration host factor subunit beta	-
EC81_RS12135	2798591..2799637	+	1047	WP_032543805.1	A/G-specific adenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (1-82)

Antitoxin

• HipA, N-terminal subdomain 1 (5-98)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13008.07 Da
• Isoelectric Point: 9.2916

>T119946 WP_032543806.1 NZ_CP036539:2795874-2796209 [Bacteroides fragilis]
MHLKNFSLYSTKPISYVLAPAYDLLSTKLVLPADSEELALTLNGKKKKIKKSDFVVAMNSTGLEDKIIENVFNKFDHLQS
KWEEFIDVSFIQETTKERYKELIHENWKRIK

Nucleotide

• Length: 336 bp

>T119946 NZ_CP036539:2795874-2796209 [Bacteroides fragilis]
ATGCATTTGAAGAACTTTTCTTTATATAGTACGAAACCTATTAGTTATGTTCTGGCACCCGCTTATGACTTACTGTCAAC
GAAGTTGGTCCTTCCTGCCGATTCTGAGGAATTGGCATTAACTCTTAATGGGAAGAAGAAGAAAATAAAGAAGTCGGACT
TTGTTGTTGCAATGAACTCGACCGGCTTGGAAGATAAGATTATTGAAAATGTTTTTAATAAGTTTGATCACCTTCAGTCT
AAATGGGAAGAGTTTATAGATGTTTCTTTTATACAAGAAACAACCAAAGAAAGGTATAAGGAGCTTATACATGAAAATTG
GAAAAGGATTAAGTGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12250.01 Da
• Isoelectric Point: 4.3184

>AT119946 WP_032543807.1 NZ_CP036539:2795546-2795872 [Bacteroides fragilis]
MKKAEIYVSNQLAGILIEDENGFSFTYTDEYISKGNRRPVSLTLPITHVPYTSSVLYPFFDGLIPEGWLLDIAEQSWKIS
SRDRMTLLLACCKDCIGDSTLLLDYGEF

Nucleotide

• Length: 327 bp

>AT119946 NZ_CP036539:2795546-2795872 [Bacteroides fragilis]
ATGAAAAAGGCTGAAATTTATGTTAGCAATCAGTTAGCCGGTATTTTGATTGAAGATGAAAATGGCTTTTCTTTCACTTA
TACAGACGAATATATTTCAAAGGGAAACCGACGACCTGTTAGTCTGACGCTTCCGATAACTCATGTCCCCTATACAAGCT
CTGTGCTGTATCCTTTCTTTGATGGATTAATTCCTGAAGGATGGTTGCTTGATATTGCGGAACAAAGTTGGAAGATAAGT
AGTCGGGATAGAATGACTTTGCTGCTGGCTTGTTGTAAGGATTGCATAGGAGATAGTACTCTTCTCTTGGATTACGGGGA
ATTCTGA