Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2078746..2079260 Replicon chromosome
Accession NZ_CP036534
Organism Streptomyces sp. VN1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6G9ES44
Locus tag EZV63_RS09180 Protein ID WP_031030578.1
Coordinates 2079006..2079260 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A6G9ESD1
Locus tag EZV63_RS09175 Protein ID WP_031030581.1
Coordinates 2078746..2079009 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EZV63_RS09160 2074588..2075448 + 861 WP_031030587.1 phosphatase PAP2 family protein -
EZV63_RS09165 2075589..2078594 - 3006 WP_166623937.1 bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase -
EZV63_RS09175 2078746..2079009 + 264 WP_031030581.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
EZV63_RS09180 2079006..2079260 + 255 WP_031030578.1 Txe/YoeB family addiction module toxin Toxin
EZV63_RS09185 2079345..2079791 + 447 WP_037764594.1 VOC family protein -
EZV63_RS09190 2079819..2081609 - 1791 WP_166623938.1 NAD+ synthase -
EZV63_RS09195 2081781..2082410 - 630 WP_166623939.1 DUF305 domain-containing protein -
EZV63_RS09200 2082407..2083075 - 669 WP_037764598.1 DUF3105 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9911.23 Da        Isoelectric Point: 9.7377

>T119943 WP_031030578.1 NZ_CP036534:2079006-2079260 [Streptomyces sp. VN1]
VRVTFTSHGWEDYVHWAESDRKVTKRINRLIDDITRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPADGVLVIVQA
RYHY

Download         Length: 255 bp

>T119943 NZ_CP036534:2079006-2079260 [Streptomyces sp. VN1]
GTGAGGGTCACTTTCACGTCCCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGGTGACCAAGCGGAT
CAACAGACTGATCGACGACATCACCCGTGACCCGTTCAAGGGCATCGGGAAGCCGGAGCCGCTCAAGGGCGACCTGTCGG
GCTACTGGTCACGGCGCATCGACGACACGCACCGGCTCGTGTACAAGCCCGCCGACGGCGTACTGGTCATCGTGCAGGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9784.92 Da        Isoelectric Point: 4.8784

>AT119943 WP_031030581.1 NZ_CP036534:2078746-2079009 [Streptomyces sp. VN1]
MPITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPKNARRLLDSIAEAEAGEARHRELI
DPDAERA

Download         Length: 264 bp

>AT119943 NZ_CP036534:2078746-2079009 [Streptomyces sp. VN1]
ATGCCCATCACCGCCAGCGAAGCCCGTCAGAACCTGTTCCCGCTGATAGAGCAGGTCAACGAGGATCATGCCCCGGTACA
CATCACCTCCCGCAAGGGAAACGCCGTACTCATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACGGTGCACCTCCTGC
GCTCGCCCAAGAACGCCCGCCGTCTGCTCGACTCCATCGCGGAGGCCGAAGCGGGCGAAGCACGGCATCGCGAGCTGATC
GACCCGGACGCGGAGCGGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G9ES44

Antitoxin

Source ID Structure
AlphaFold DB A0A6G9ESD1

References