119942

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3437621..3438279 Replicon chromosome
Accession NZ_CP036532
Organism Roseitalea porphyridii strain MA7-20

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E0E05_RS16825 Protein ID WP_131617743.1
Coordinates 3437923..3438279 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E0E05_RS16820 Protein ID WP_131617742.1
Coordinates 3437621..3437905 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E05_RS16805 3433413..3436106 - 2694 WP_131617739.1 aconitate hydratase AcnA -
E0E05_RS16810 3436326..3436940 + 615 WP_131617740.1 heme ABC exporter ATP-binding protein CcmA -
E0E05_RS16815 3436937..3437602 + 666 WP_131617741.1 heme exporter protein CcmB -
E0E05_RS16820 3437621..3437905 - 285 WP_131617742.1 helix-turn-helix domain-containing protein Antitoxin
E0E05_RS16825 3437923..3438279 - 357 WP_131617743.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E0E05_RS16830 3438361..3438825 + 465 WP_131617744.1 hypothetical protein -
E0E05_RS16835 3438895..3439680 + 786 WP_131617745.1 heme ABC transporter permease -
E0E05_RS16840 3439685..3439858 + 174 WP_131617746.1 heme exporter protein CcmD -
E0E05_RS16845 3439855..3440472 + 618 WP_131617747.1 DsbE family thiol:disulfide interchange protein -
E0E05_RS16850 3440490..3441734 - 1245 WP_131617748.1 MFS transporter -
E0E05_RS16855 3441800..3442177 + 378 WP_131617749.1 YggT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(4-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-87)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12511.26 Da        Isoelectric Point: 10.6179

>T119942 WP_131617743.1 NZ_CP036532:c3438279-3437923 [Roseitalea porphyridii]
MHTVVTTSVFERHAKAAGLSEEELSGIIAYLADNPKAGSVIPGTGGARKVRFAGAGKGKRGGYRTIHYFAADDVPIFLLA
LVKKGDRADISQAERDALAATLPRIAEAYRTGSGARRR

Download         Length: 357 bp

>T119942 NZ_CP036532:c3438279-3437923 [Roseitalea porphyridii]
ATGCACACGGTTGTCACGACGTCGGTCTTCGAGCGGCACGCAAAGGCGGCTGGCCTTTCCGAAGAGGAGTTGAGCGGCAT
CATTGCATATCTTGCCGACAACCCGAAAGCGGGATCGGTGATTCCTGGGACAGGCGGTGCGCGGAAAGTGCGCTTTGCGG
GCGCCGGCAAGGGCAAGCGCGGTGGTTACCGCACGATCCACTATTTCGCGGCCGATGACGTGCCGATTTTCCTGCTGGCG
CTCGTCAAGAAGGGCGACAGAGCCGATATCAGCCAGGCCGAGCGTGACGCGCTTGCCGCGACCTTGCCCAGGATCGCGGA
GGCATACCGGACAGGGTCGGGCGCCAGAAGAAGATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10383.93 Da        Isoelectric Point: 10.3413

>AT119942 WP_131617742.1 NZ_CP036532:c3437905-3437621 [Roseitalea porphyridii]
MSKFGRELVESAEEALAIAKAEKAPSRMVVPAKTDVAALRRRLGLTQAGFAARYGLNVATVRDWEQNRRQPDQPARVLLK
VIENDPEAVERALA

Download         Length: 285 bp

>AT119942 NZ_CP036532:c3437905-3437621 [Roseitalea porphyridii]
ATGAGCAAGTTTGGCCGGGAACTGGTCGAGAGCGCCGAGGAAGCATTGGCCATCGCCAAGGCCGAAAAGGCCCCATCCCG
CATGGTCGTACCCGCCAAGACCGACGTGGCCGCGTTGCGGCGGCGCCTCGGGCTGACGCAGGCCGGCTTTGCCGCCCGCT
ATGGCCTGAACGTTGCCACCGTCCGTGACTGGGAACAGAACCGCCGGCAACCCGACCAGCCGGCCCGCGTGCTGCTGAAG
GTCATCGAAAACGATCCGGAAGCCGTCGAGCGGGCGCTCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References