119939

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2690739..2691338 Replicon chromosome
Accession NZ_CP036532
Organism Roseitalea porphyridii strain MA7-20

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag E0E05_RS13050 Protein ID WP_131617114.1
Coordinates 2690739..2691020 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag E0E05_RS13055 Protein ID WP_131617115.1
Coordinates 2691030..2691338 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0E05_RS13030 2686494..2687522 + 1029 WP_131617110.1 TAXI family TRAP transporter solute-binding subunit -
E0E05_RS13035 2687604..2689706 + 2103 WP_131617111.1 TRAP transporter fused permease subunit -
E0E05_RS13040 2689747..2690025 + 279 WP_131617112.1 type II toxin-antitoxin system RelE/ParE family toxin -
E0E05_RS13045 2690025..2690324 + 300 WP_131617113.1 HigA family addiction module antidote protein -
E0E05_RS13050 2690739..2691020 + 282 WP_131617114.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E0E05_RS13055 2691030..2691338 + 309 WP_131617115.1 HigA family addiction module antidote protein Antitoxin
E0E05_RS13060 2691385..2691936 - 552 WP_131617116.1 dihydrofolate reductase -
E0E05_RS13065 2691936..2692940 - 1005 WP_131617117.1 DUF4424 domain-containing protein -
E0E05_RS13070 2692940..2693734 - 795 WP_131617118.1 thymidylate synthase -
E0E05_RS13075 2693966..2694277 - 312 WP_131617119.1 DUF2853 family protein -
E0E05_RS13085 2694915..2695445 + 531 WP_131617120.1 SspB family protein -
E0E05_RS13090 2695465..2695755 + 291 WP_131617121.1 ribbon-helix-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10510.09 Da        Isoelectric Point: 9.6276

>T119939 WP_131617114.1 NZ_CP036532:2690739-2691020 [Roseitalea porphyridii]
MIVGYRDKRTEVIAGRACPKGFPADVFKAAYRKLAMLEAAGALDDLRSPPGNRLEALKGDRKGQHSVRINDQWRICFVWT
PQGPDRVEIVDYH

Download         Length: 282 bp

>T119939 NZ_CP036532:2690739-2691020 [Roseitalea porphyridii]
ATGATCGTCGGCTATCGGGACAAGCGCACCGAGGTGATTGCGGGGCGCGCATGCCCGAAGGGGTTTCCGGCCGATGTCTT
CAAGGCGGCCTACCGGAAGCTTGCGATGCTGGAAGCCGCCGGCGCGTTGGACGACCTTCGCTCACCGCCCGGCAATCGGC
TGGAGGCGCTCAAGGGTGACCGCAAGGGGCAGCATTCGGTGCGGATCAACGACCAGTGGCGTATCTGCTTCGTCTGGACG
CCGCAGGGGCCCGACCGGGTCGAGATCGTCGACTATCATTAG

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11659.44 Da        Isoelectric Point: 10.8284

>AT119939 WP_131617115.1 NZ_CP036532:2691030-2691338 [Roseitalea porphyridii]
MPNRTATRPMPAVHPGEVLREEFLIPYRMSAYQLAKAIKVPRTRVERIAKEQTAVTSDTALRLARFFGTSSQFWMNLQAN
HDLARASEHVELDEIKPLRRAG

Download         Length: 309 bp

>AT119939 NZ_CP036532:2691030-2691338 [Roseitalea porphyridii]
ATGCCGAACCGCACAGCGACACGACCGATGCCCGCCGTCCATCCGGGCGAAGTGCTGCGCGAGGAATTTCTGATCCCCTA
CCGGATGAGCGCCTACCAGCTCGCCAAGGCGATCAAGGTGCCGCGCACGCGCGTCGAACGGATCGCCAAGGAGCAGACGG
CAGTGACGTCGGACACGGCCCTGCGGCTGGCGCGATTCTTCGGAACCTCGTCGCAATTCTGGATGAACCTGCAGGCCAAC
CACGATCTGGCGCGCGCATCCGAGCATGTCGAACTCGACGAGATCAAACCGCTACGACGGGCGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References