Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4218055..4218751 Replicon chromosome
Accession NZ_CP036514
Organism Hafnia alvei strain PCM_1220

Toxin (Protein)


Gene name mqsR Uniprot ID A0A097R795
Locus tag EYZ02_RS19520 Protein ID WP_025799365.1
Coordinates 4218440..4218751 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A097R796
Locus tag EYZ02_RS19515 Protein ID WP_025799364.1
Coordinates 4218055..4218453 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYZ02_RS19505 4213685..4216132 + 2448 WP_131392455.1 glycogen phosphorylase -
EYZ02_RS19510 4216328..4217812 - 1485 WP_025799362.1 glycerol-3-phosphate dehydrogenase -
EYZ02_RS19515 4218055..4218453 - 399 WP_025799364.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
EYZ02_RS19520 4218440..4218751 - 312 WP_025799365.1 type II toxin-antitoxin system MqsR family toxin Toxin
EYZ02_RS19525 4219007..4219765 - 759 WP_131392457.1 DeoR/GlpR family transcriptional regulator -
EYZ02_RS19530 4219812..4220648 - 837 WP_043489475.1 rhomboid family intramembrane serine protease GlpG -
EYZ02_RS19535 4220696..4221025 - 330 WP_025799370.1 thiosulfate sulfurtransferase GlpE -
EYZ02_RS19540 4221299..4221730 + 432 WP_131392459.1 hypothetical protein -
EYZ02_RS19545 4221864..4222622 - 759 WP_131392461.1 glycerophosphodiester phosphodiesterase -
EYZ02_RS19550 4222656..4223732 - 1077 WP_130994725.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Antitoxin MqsA

(3-131)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12064.97 Da        Isoelectric Point: 7.1032

>T119924 WP_025799365.1 NZ_CP036514:c4218751-4218440 [Hafnia alvei]
MEKRTPHCSLEKVRNLIGKGMVRITKSAHRDAELIHFGLADMYRVVCELSPQDFYKSMTTYDDHRIWQDVYHCHLDKVSL
YLKLTVVDDVLIVSFKELDHALS

Download         Length: 312 bp

>T119924 NZ_CP036514:c4218751-4218440 [Hafnia alvei]
ATGGAGAAGCGAACGCCGCATTGTAGCTTGGAAAAGGTACGGAACTTGATTGGGAAGGGGATGGTTAGGATAACCAAATC
AGCGCACCGCGATGCTGAGCTGATACATTTTGGCCTAGCTGATATGTATCGCGTTGTCTGTGAACTTTCGCCTCAAGATT
TTTATAAGAGCATGACAACTTATGATGACCATCGTATCTGGCAGGATGTTTACCATTGCCATCTGGACAAGGTGTCTCTC
TATCTGAAATTAACGGTTGTTGATGATGTCCTCATCGTTTCGTTTAAGGAGTTAGATCATGCACTGTCCTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14759.92 Da        Isoelectric Point: 5.7723

>AT119924 WP_025799364.1 NZ_CP036514:c4218453-4218055 [Hafnia alvei]
MHCPECGSKNTIKDYRDIPFTYKGQSTVVKAVGADWCLDCGEGVIFKDESLRIDSILTEFNKQVNASIIDPEYVVAMRKK
LNLSQSEAGEIFGGGVNAFSRYETGKALPHVSTIKLLKLLDKYPELLEEIRN

Download         Length: 399 bp

>AT119924 NZ_CP036514:c4218453-4218055 [Hafnia alvei]
ATGCACTGTCCTGAGTGTGGTTCGAAAAATACGATTAAAGATTACCGTGACATTCCATTTACCTATAAAGGGCAGTCTAC
AGTGGTTAAAGCTGTGGGGGCTGACTGGTGTTTAGACTGCGGTGAAGGCGTAATTTTTAAAGACGAATCTCTGCGTATCG
ACAGCATTTTGACGGAGTTCAATAAGCAGGTTAATGCGTCCATCATCGATCCTGAGTACGTGGTGGCAATGCGAAAAAAG
CTGAACCTTTCCCAAAGTGAAGCCGGTGAGATCTTTGGCGGCGGTGTGAACGCATTTTCGCGCTACGAAACTGGCAAGGC
GCTGCCCCATGTATCAACCATCAAGTTGCTAAAATTGCTTGATAAATATCCAGAATTGCTCGAAGAAATTCGTAACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097R795

Antitoxin

Source ID Structure
AlphaFold DB A0A097R796

References