Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5350946..5351530 Replicon chromosome
Accession NZ_CP036498
Organism Rhodopseudomonas sp. SK50-23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag RPMA_RS25590 Protein ID WP_211910440.1
Coordinates 5351246..5351530 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RPMA_RS25585 Protein ID WP_249225408.1
Coordinates 5350946..5351236 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RPMA_RS25570 (RPMA_25315) 5346802..5348832 + 2031 WP_211910437.1 TRAP transporter fused permease subunit -
RPMA_RS25575 (RPMA_25320) 5348908..5349864 + 957 WP_211910438.1 TAXI family TRAP transporter solute-binding subunit -
RPMA_RS25580 (RPMA_25325) 5349904..5350875 + 972 WP_211910439.1 TAXI family TRAP transporter solute-binding subunit -
RPMA_RS25585 (RPMA_25330) 5350946..5351236 - 291 WP_249225408.1 HigA family addiction module antitoxin Antitoxin
RPMA_RS25590 (RPMA_25335) 5351246..5351530 - 285 WP_211910440.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RPMA_RS25595 (RPMA_25340) 5351659..5352906 + 1248 WP_249225409.1 MFS transporter -
RPMA_RS25600 (RPMA_25345) 5353000..5353992 + 993 WP_211910442.1 tripartite tricarboxylate transporter substrate binding protein -
RPMA_RS25605 (RPMA_25350) 5354055..5354531 - 477 WP_211913827.1 hypothetical protein -
RPMA_RS25610 (RPMA_25355) 5354787..5355059 + 273 WP_249225766.1 hypothetical protein -
RPMA_RS25615 (RPMA_25360) 5355172..5356419 + 1248 WP_211910444.1 bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase ArgJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-94)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(10-94)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10855.60 Da        Isoelectric Point: 8.9793

>T119894 WP_211910440.1 NZ_CP036498:c5351530-5351246 [Rhodopseudomonas sp. SK50-23]
MIKTFADKRTAEIFAGKPIKKGFPGDIVIVARRKLDMLDNATTLESLKLPPSNKLHPLKDERKGQHAIWINSQWRLCFVW
MDGDAYDVEITDYH

Download         Length: 285 bp

>T119894 NZ_CP036498:c5351530-5351246 [Rhodopseudomonas sp. SK50-23]
ATGATCAAGACGTTCGCCGACAAGCGGACTGCCGAGATTTTCGCTGGGAAGCCCATCAAAAAGGGCTTTCCGGGCGATAT
CGTTATCGTGGCCCGCCGCAAGTTGGACATGCTCGACAATGCGACGACCCTCGAAAGTCTGAAGCTGCCGCCGAGCAACA
AGCTTCATCCGTTGAAGGACGAACGAAAAGGGCAGCATGCCATTTGGATCAATAGCCAATGGCGTCTTTGTTTCGTCTGG
ATGGACGGTGATGCCTACGACGTCGAAATCACTGATTATCATTAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10648.32 Da        Isoelectric Point: 8.7087

>AT119894 WP_249225408.1 NZ_CP036498:c5351236-5350946 [Rhodopseudomonas sp. SK50-23]
MSISRDKVQMHRLPTTPGEMLLKEFMEPNEISARALARDLGVPPNRITGIINGKRAITADTAVLLEGRLGMPGEFWMNLQ
SNYDLAVARQRQAEAA

Download         Length: 291 bp

>AT119894 NZ_CP036498:c5351236-5350946 [Rhodopseudomonas sp. SK50-23]
ATGAGCATCTCACGCGATAAAGTTCAGATGCACCGTCTCCCGACGACGCCTGGCGAGATGCTGCTCAAGGAATTCATGGA
GCCGAATGAAATTTCGGCGCGTGCACTCGCGCGTGATCTCGGTGTCCCGCCAAATCGCATCACGGGCATCATAAATGGGA
AGCGCGCGATCACTGCCGATACGGCGGTGCTGCTCGAAGGCCGCCTTGGCATGCCCGGCGAATTCTGGATGAACCTGCAA
TCGAATTACGATCTGGCCGTCGCCCGGCAGCGGCAGGCGGAAGCGGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References