Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2006517..2007130 Replicon chromosome
Accession NZ_CP036498
Organism Rhodopseudomonas sp. SK50-23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag RPMA_RS09440 Protein ID WP_211912564.1
Coordinates 2006517..2006813 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag RPMA_RS09445 Protein ID WP_211912565.1
Coordinates 2006822..2007130 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RPMA_RS09420 (RPMA_09370) 2002522..2002722 + 201 WP_211912560.1 DUF2065 domain-containing protein -
RPMA_RS09425 (RPMA_09375) 2002910..2004424 + 1515 WP_211912561.1 Do family serine endopeptidase -
RPMA_RS09430 (RPMA_09380) 2004635..2005537 - 903 WP_211912562.1 phosphoserine phosphatase SerB -
RPMA_RS09435 (RPMA_09385) 2005541..2006464 + 924 WP_211912563.1 tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA -
RPMA_RS09440 (RPMA_09390) 2006517..2006813 + 297 WP_211912564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
RPMA_RS09445 (RPMA_09395) 2006822..2007130 + 309 WP_211912565.1 HigA family addiction module antitoxin Antitoxin
RPMA_RS09450 (RPMA_09400) 2007198..2008298 - 1101 WP_211912566.1 tyrosinase family protein -
RPMA_RS09455 (RPMA_09405) 2008307..2008684 + 378 WP_211912567.1 hypothetical protein -
RPMA_RS09460 (RPMA_09410) 2008870..2010648 + 1779 WP_211912568.1 acetolactate synthase 3 large subunit -
RPMA_RS09465 (RPMA_09415) 2010844..2011386 + 543 WP_211912569.1 acetolactate synthase small subunit -
RPMA_RS09470 (RPMA_09420) 2011442..2011804 + 363 WP_211912570.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11591.09 Da        Isoelectric Point: 6.7252

>T119888 WP_211912564.1 NZ_CP036498:2006517-2006813 [Rhodopseudomonas sp. SK50-23]
MIVGFRDGWLQSFFVDDVRSRHIPSDLESRLFRRLQMIDDAVTDLDLRMPPSNHFEKLRGTLAGFYSIRVNDQWRLIFRW
DGARGEAAGVYLDDHSYR

Download         Length: 297 bp

>T119888 NZ_CP036498:2006517-2006813 [Rhodopseudomonas sp. SK50-23]
ATGATCGTAGGATTTCGCGATGGCTGGCTGCAATCCTTCTTCGTGGACGATGTACGTTCTCGCCATATTCCGAGCGACCT
CGAAAGTCGGCTGTTTCGTAGACTTCAGATGATCGATGACGCTGTCACCGACCTGGATCTCCGCATGCCGCCGAGCAATC
ATTTCGAGAAGCTGCGGGGCACGCTTGCTGGCTTTTACTCGATCCGTGTCAACGATCAGTGGCGGCTGATTTTCCGCTGG
GACGGCGCCCGAGGTGAGGCCGCTGGTGTTTATCTCGACGATCATAGTTATAGGTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11454.30 Da        Isoelectric Point: 10.5835

>AT119888 WP_211912565.1 NZ_CP036498:2006822-2007130 [Rhodopseudomonas sp. SK50-23]
MLMTKRKPATIGEILSEEFMQPLGLTQGALADAMGVQRKHVNELCNDRRGVTAATALILARVFGNSPDFWLNVQRRNDLW
QAMHSPEERARIERAKPLVKAA

Download         Length: 309 bp

>AT119888 NZ_CP036498:2006822-2007130 [Rhodopseudomonas sp. SK50-23]
ATGCTCATGACCAAGCGCAAGCCGGCGACGATTGGCGAGATTCTCTCTGAGGAATTCATGCAGCCGCTCGGCCTGACGCA
GGGCGCGCTTGCTGATGCCATGGGCGTACAGCGCAAGCATGTGAACGAGCTATGCAATGATCGCCGCGGCGTGACAGCCG
CAACCGCGCTCATTCTCGCGCGCGTATTTGGCAATAGTCCGGACTTCTGGCTGAACGTTCAGCGCCGAAATGATCTCTGG
CAAGCGATGCATTCCCCCGAAGAACGTGCCCGGATCGAACGCGCCAAACCGCTGGTGAAGGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References