Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 334037..334703 Replicon chromosome
Accession NZ_CP036435
Organism Citrobacter sp. ABFQG

Toxin (Protein)


Gene name higB Uniprot ID A0A8B5Q945
Locus tag WN16_RS01780 Protein ID WP_003847996.1
Coordinates 334037..334354 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4U6IRD5
Locus tag WN16_RS01785 Protein ID WP_003837894.1
Coordinates 334407..334703 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
WN16_RS01765 329207..330085 + 879 WP_003023531.1 Hsp33 family molecular chaperone HslO -
WN16_RS01770 330195..331913 - 1719 WP_047715944.1 DUF4153 domain-containing protein -
WN16_RS01775 332292..333914 + 1623 WP_044701411.1 phosphoenolpyruvate carboxykinase (ATP) -
WN16_RS01780 334037..334354 + 318 WP_003847996.1 hypothetical protein Toxin
WN16_RS01785 334407..334703 + 297 WP_003837894.1 helix-turn-helix domain-containing protein Antitoxin
WN16_RS01790 334760..336112 - 1353 WP_003837891.1 two-component system sensor histidine kinase EnvZ -
WN16_RS01795 336109..336828 - 720 WP_001157751.1 two-component system response regulator OmpR -
WN16_RS01800 337054..337527 + 474 WP_003023524.1 transcription elongation factor GreB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12225.15 Da        Isoelectric Point: 10.0909

>T119762 WP_003847996.1 NZ_CP036435:334037-334354 [Citrobacter sp. ABFQG]
MFTFIELQGFSKRRPLLLPDDEFRAFQEALIENPEAGDTIAGTGGFRKIRWSRSGMGKRSGIRVIYYNVTRKGRIYLALL
YPKNEQDDLTEEQKRVLMHLSNMLI

Download         Length: 318 bp

>T119762 NZ_CP036435:334037-334354 [Citrobacter sp. ABFQG]
ATGTTCACATTTATTGAGCTACAAGGATTTAGTAAACGCCGTCCGTTACTTTTGCCTGACGATGAGTTTCGCGCTTTTCA
AGAGGCGCTTATAGAGAACCCTGAGGCTGGAGATACTATCGCTGGTACAGGTGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGCAAACGCAGCGGTATTAGGGTTATCTATTACAACGTGACGCGCAAAGGTCGAATCTATCTCGCTTTGCTC
TATCCTAAAAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCAATATGCTGATTTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11157.93 Da        Isoelectric Point: 7.2050

>AT119762 WP_003837894.1 NZ_CP036435:334407-334703 [Citrobacter sp. ABFQG]
MKDELFADLLASAEEMVRIEKGEETPKPEHVHTFSEIDVKAIREATGLRQQDFAIAVGVSYDLVKSWETKRRQPTGAPRK
LLLLIQKNPFIINQLKAI

Download         Length: 297 bp

>AT119762 NZ_CP036435:334407-334703 [Citrobacter sp. ABFQG]
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTGCGTATAGAGAAAGGTGAAGAAACACCTAA
GCCTGAACATGTACATACCTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCTGTTGGCGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAGCCGACTGGTGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAATCCATTTATAATTAATCAATTAAAAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B5Q945

Antitoxin

Source ID Structure
AlphaFold DB A0A4U6IRD5

References