Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1071496..1072153 Replicon chromosome
Accession NZ_CP036310
Organism Enterobacter hormaechei strain WCHEH090011

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EKN58_RS05330 Protein ID WP_032609983.1
Coordinates 1071854..1072153 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EKN58_RS05325 Protein ID WP_032609984.1
Coordinates 1071496..1071843 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKN58_RS05300 1066830..1067828 + 999 WP_022651706.1 transketolase family protein -
EKN58_RS05305 1067903..1068634 + 732 WP_042863460.1 class I SAM-dependent methyltransferase -
EKN58_RS05310 1068631..1069233 - 603 WP_022651704.1 short chain dehydrogenase -
EKN58_RS05315 1069331..1070218 + 888 WP_022651703.1 LysR family transcriptional regulator -
EKN58_RS05320 1070239..1071420 + 1182 WP_023314694.1 PLP-dependent aminotransferase family protein -
EKN58_RS05325 1071496..1071843 - 348 WP_032609984.1 HigA family addiction module antidote protein Antitoxin
EKN58_RS05330 1071854..1072153 - 300 WP_032609983.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EKN58_RS05335 1072404..1073564 - 1161 WP_087920848.1 HlyD family efflux transporter periplasmic adaptor subunit -
EKN58_RS05340 1073584..1075776 - 2193 WP_032609980.1 type I secretion system permease/ATPase -
EKN58_RS05345 1075773..1076480 - 708 Protein_1022 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-103)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11610.24 Da        Isoelectric Point: 9.6776

>T119539 WP_032609983.1 NZ_CP036310:c1072153-1071854 [Enterobacter hormaechei]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNIYEALSPTLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

>T119539 NZ_CP036310:c1072153-1071854 [Enterobacter hormaechei]
ATGATTAATCATTTTCGGGATCAATGGCTTGAGGATTTTTTTCTCTACGGGAGATCGAGCAATGTTATTCCTTTGAATCT
GGAAACAGCGCTTGCAAGAAAGCTCGACATCATCAATGCGGCCATGTCGCACCTGGATTTACGATCGCCACCGGGCAATA
TATATGAAGCATTGAGTCCTACGTTGAAGGGATACTCCTCTATCCGGGTAAACAGACAATACAGGCTTGTATTTCGCTGG
TCAGAGGGAAAAGCAGACGATCTCTATCTCTCTCCACACAAGTACACGCAACACAAGTGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13094.06 Da        Isoelectric Point: 9.5932

>AT119539 WP_032609984.1 NZ_CP036310:c1071843-1071496 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEVLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWETQSNSRTQEELSRIKTVAEVMAKRKSGKPDVA

Download         Length: 348 bp

>AT119539 NZ_CP036310:c1071843-1071496 [Enterobacter hormaechei]
ATGACACTTCAACAGGCACTCCGCAAACCCACCACGCCGGGCGAGGTGTTGCAGTATGAGTATCTTGAACCGCTCAATCT
GAAAATCAACGATCTGGCAGAGGTGCTAAATGTACACCGCAATACCGTAAGCGCGTTGGTCAATAACAATCGCAAACTTA
CTGCCGATATGGCGATCAAACTGGCAAAAGCCTTTAATACCACTATTGAATTTTGGCTGAACTTACAGCTAAACGTTGAT
ATCTGGGAAACGCAATCTAACTCCCGCACGCAGGAGGAGTTAAGCCGGATAAAAACCGTTGCGGAAGTCATGGCGAAGCG
AAAATCCGGCAAGCCGGACGTTGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References