Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 808816..809491 Replicon chromosome
Accession NZ_CP036282
Organism Rhodoferax sediminis strain Gr-4

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EXZ61_RS03830 Protein ID WP_142809194.1
Coordinates 809150..809491 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EXZ61_RS03825 Protein ID WP_142809192.1
Coordinates 808816..809163 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXZ61_RS03790 803997..804404 + 408 WP_142809178.1 Co2+/Mg2+ efflux protein ApaG -
EXZ61_RS03795 804413..805435 + 1023 WP_142809180.1 thiamine-phosphate kinase -
EXZ61_RS03800 805466..805666 - 201 WP_142809182.1 YjfB family protein -
EXZ61_RS03805 805773..806930 + 1158 WP_142809184.1 carboxypeptidase family protein -
EXZ61_RS03810 806993..807232 + 240 WP_142809186.1 hypothetical protein -
EXZ61_RS03815 807395..807862 - 468 WP_142809188.1 VOC family protein -
EXZ61_RS03820 808049..808792 - 744 WP_142809190.1 VOC family protein -
EXZ61_RS03825 808816..809163 - 348 WP_142809192.1 helix-turn-helix transcriptional regulator Antitoxin
EXZ61_RS03830 809150..809491 - 342 WP_142809194.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EXZ61_RS03835 809576..810481 - 906 WP_142809196.1 GIY-YIG nuclease family protein -
EXZ61_RS03840 810856..811749 - 894 WP_142809198.1 EamA family transporter -
EXZ61_RS03845 811772..812695 - 924 WP_168224695.1 LysR family transcriptional regulator -
EXZ61_RS03850 812762..814324 + 1563 WP_142809203.1 M20 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13148.57 Da        Isoelectric Point: 10.0185

>T119468 WP_142809194.1 NZ_CP036282:c809491-809150 [Rhodoferax sediminis]
IFSGKWEIKYHDEKLQADVLALPPGILARYFHCTDRMVEFGPDLGMPHTRAMSMGLFELRLKSREGIGRVFYCTLVDRKI
VMLHQCVKKTDKTPPKELALARKRMKEWKNVDA

Download         Length: 342 bp

>T119468 NZ_CP036282:c809491-809150 [Rhodoferax sediminis]
ATTTTCAGCGGGAAATGGGAGATCAAATATCACGATGAGAAGTTGCAGGCTGATGTGCTGGCGTTACCGCCGGGAATTTT
GGCCAGATACTTTCATTGCACCGACCGCATGGTGGAGTTTGGTCCTGATTTAGGAATGCCTCACACGCGGGCAATGAGCA
TGGGGCTCTTCGAGTTGCGTTTGAAATCCCGTGAGGGTATTGGACGGGTGTTTTATTGCACCTTGGTGGATCGCAAGATC
GTCATGCTCCATCAATGTGTGAAGAAGACCGATAAGACACCTCCCAAAGAATTGGCACTTGCGCGTAAGCGAATGAAGGA
GTGGAAAAATGTTGACGCATAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 12460.28 Da        Isoelectric Point: 10.2130

>AT119468 WP_142809192.1 NZ_CP036282:c809163-808816 [Rhodoferax sediminis]
MLTHKQLRTKALANAEVKAEYEQLADEFSLLDEFLKARAAQGLTQAQVAEKIGTTQSAVARMESGSGKHSPSLATLTKYA
DALGCKLEVRLVRRLQPANNLTDRPSPATPKRVAA

Download         Length: 348 bp

>AT119468 NZ_CP036282:c809163-808816 [Rhodoferax sediminis]
ATGTTGACGCATAAACAACTTCGTACTAAGGCACTGGCTAATGCTGAGGTAAAGGCGGAATACGAACAACTGGCCGACGA
GTTTTCTCTTTTGGATGAGTTCTTGAAGGCGCGGGCTGCGCAAGGCCTGACCCAGGCGCAGGTGGCAGAAAAGATCGGCA
CTACGCAGTCTGCAGTTGCACGCATGGAGTCGGGTAGTGGCAAGCATTCTCCTTCTCTGGCGACGCTGACCAAGTATGCG
GATGCCCTGGGGTGCAAGCTGGAGGTTCGGTTGGTTCGCAGGCTTCAGCCAGCGAACAACTTAACGGATCGTCCAAGCCC
GGCAACGCCCAAGCGCGTTGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References