Detailed information of TA system TA119454

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 5012087..5012673
• Replicon: chromosome
• Accession: NZ_CP036254
• Organism: Xanthomonas oryzae strain BB156-2

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: EYC55_RS23490
• Protein ID: WP_131076070.1
• Coordinates: 5012395..5012673 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EYC55_RS23485
• Protein ID: WP_053503948.1
• Coordinates: 5012087..5012377 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYC55_RS23445	5007350..5007826	-	477	WP_053501997.1	DUF4123 domain-containing protein	-
EYC55_RS23450	5007829..5008263	-	435	WP_131085566.1	PAAR domain-containing protein	-
EYC55_RS23455	5008379..5008624	-	246	WP_024743556.1	hypothetical protein	-
EYC55_RS23465	5008960..5009292	+	333	WP_003482333.1	hypothetical protein	-
EYC55_RS23475	5009744..5011138	-	1395	WP_053503949.1	nucleoside hydrolase	-
EYC55_RS23485	5012087..5012377	-	291	WP_053503948.1	HigA family addiction module antidote protein	Antitoxin
EYC55_RS23490	5012395..5012673	-	279	WP_131076070.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EYC55_RS23495	5012771..5015032	-	2262	WP_131085568.1	exodeoxyribonuclease V subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4983847..5015032	31185

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (13-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-68)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10843.50 Da
• Isoelectric Point: 9.3215

>T119454 WP_131076070.1 NZ_CP036254:c5012673-5012395 [Xanthomonas oryzae]
ISSVIDKDAEKIRLGERSRRLPAESQMVARRKLRMLDAAAHPEDLRIPPANRLEALKGQWRGQCSIRINDQWRICFRWME
GDVFQVEIVDYH

Nucleotide

• Length: 279 bp

>T119454 NZ_CP036254:c5012673-5012395 [Xanthomonas oryzae]
ATCAGCAGCGTTATCGACAAGGACGCTGAAAAGATCCGGCTGGGTGAGCGTTCCCGCCGATTGCCGGCCGAGAGTCAGAT
GGTGGCGCGCCGCAAGTTGCGCATGCTCGATGCCGCCGCGCATCCCGAAGATCTGCGGATTCCGCCCGCCAACCGGCTGG
AAGCGTTGAAGGGCCAGTGGCGCGGCCAGTGCAGCATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATGGAA
GGCGATGTGTTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10345.95 Da
• Isoelectric Point: 6.4654

>AT119454 WP_053503948.1 NZ_CP036254:c5012377-5012087 [Xanthomonas oryzae]
MTVLANIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADDELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT119454 NZ_CP036254:c5012377-5012087 [Xanthomonas oryzae]
ATGACAGTCCTAGCCAATATCCACCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGCATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTTGGCCTGCAGGCCGACGACGAACTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA