Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 3409723..3410310 Replicon chromosome
Accession NZ_CP036250
Organism Egicoccus halophilus strain EGI 80432

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag ELR47_RS15490 Protein ID WP_130650703.1
Coordinates 3409723..3410004 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag ELR47_RS15495 Protein ID WP_130650704.1
Coordinates 3410014..3410310 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ELR47_RS15460 3407049..3407363 + 315 WP_130648066.1 transposase -
ELR47_RS15465 3407360..3408265 + 906 WP_165404127.1 IS3 family transposase -
ELR47_RS15470 3408500..3408769 - 270 WP_130650699.1 hypothetical protein -
ELR47_RS15475 3408771..3409097 - 327 WP_130650700.1 hypothetical protein -
ELR47_RS15480 3409086..3409331 + 246 WP_130650701.1 addiction module protein -
ELR47_RS15485 3409328..3409633 + 306 WP_130650702.1 type II toxin-antitoxin system RelE/ParE family toxin -
ELR47_RS15490 3409723..3410004 + 282 WP_130650703.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ELR47_RS15495 3410014..3410310 + 297 WP_130650704.1 HigA family addiction module antidote protein Antitoxin
ELR47_RS15500 3410442..3410654 + 213 WP_130649563.1 type II toxin-antitoxin system HicA family toxin -
ELR47_RS15505 3410651..3411058 + 408 WP_130649562.1 helix-turn-helix domain-containing protein -
ELR47_RS15510 3411082..3411678 - 597 WP_130650705.1 MFS transporter -
ELR47_RS15515 3412137..3412802 - 666 WP_205745312.1 NAD(P)H-binding protein -
ELR47_RS15520 3412882..3414180 - 1299 WP_130650707.1 amidase -
ELR47_RS15525 3414177..3414887 - 711 WP_130650708.1 carbon monoxide dehydrogenase subunit G -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3384147..3413393 29246


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11141.73 Da        Isoelectric Point: 10.5256

>T119444 WP_130650703.1 NZ_CP036250:3409723-3410004 [Egicoccus halophilus]
MIRSFRDRDTERLAARQRVKRWPPELSKAALRKLRMLDAAEELIDLRAPPGNRLERLKGDRQGQHSIRINDQWRICFRWE
AGNAYDVEIVDYH

Download         Length: 282 bp

>T119444 NZ_CP036250:3409723-3410004 [Egicoccus halophilus]
ATGATCCGCAGCTTCCGCGACCGCGACACCGAACGCCTCGCTGCGCGGCAGCGGGTCAAGAGGTGGCCTCCTGAACTGAG
CAAGGCTGCCCTGCGCAAGCTGCGGATGCTCGATGCCGCCGAGGAACTCATCGACCTGCGCGCCCCTCCCGGCAACCGAC
TCGAACGGCTGAAGGGCGACCGGCAAGGACAGCACTCCATCCGCATCAACGACCAGTGGCGCATCTGCTTCCGATGGGAG
GCCGGCAACGCCTACGACGTCGAGATCGTGGACTACCACTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11081.66 Da        Isoelectric Point: 7.3194

>AT119444 WP_130650704.1 NZ_CP036250:3410014-3410310 [Egicoccus halophilus]
METKLPPVHPGEVLLEEFLAPTGLSQYRLAKDISVPPRRINEIVHGKRAVTADTALRLARRLGTTPRFWLNLQAQYDLDV
ETDRLGDRLDREVAAHAN

Download         Length: 297 bp

>AT119444 NZ_CP036250:3410014-3410310 [Egicoccus halophilus]
ATGGAGACGAAGCTCCCACCCGTCCACCCCGGCGAAGTGCTCCTCGAGGAGTTTCTCGCACCGACCGGGCTGTCGCAGTA
CCGGCTCGCCAAGGACATCAGCGTCCCACCCCGTCGCATCAACGAAATCGTGCACGGCAAGCGCGCCGTCACCGCTGACA
CCGCCCTACGGCTAGCCCGCCGCCTCGGCACCACCCCGCGGTTCTGGCTCAACCTTCAGGCCCAGTACGACCTCGACGTC
GAAACCGACCGCCTCGGCGACCGACTCGACCGCGAGGTCGCCGCGCACGCCAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References