Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 3409723..3410310 Replicon chromosome
Accession NZ_CP036250
Organism Egicoccus halophilus strain EGI 80432

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag ELR47_RS15490 Protein ID WP_130650703.1
Coordinates 3409723..3410004 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag ELR47_RS15495 Protein ID WP_130650704.1
Coordinates 3410014..3410310 (+) Length 99 a.a.

Genomic Context

ELR47_RS15460ELR47_RS15465ELR47_RS15480ELR47_RS15485ELR47_RS15490ELR47_RS15495ELR47_RS15500ELR47_RS15505ELR47_RS15470ELR47_RS15475ELR47_RS15510ELR47_RS15515ELR47_RS15520ELR47_RS15525
Location: 3407049..3407363 (315 bp)
Type: Others
Protein ID: WP_130648066.1
Location: 3407360..3408265 (906 bp)
Type: Others
Protein ID: WP_165404127.1
Location: 3409086..3409331 (246 bp)
Type: Others
Protein ID: WP_130650701.1
Location: 3409328..3409633 (306 bp)
Type: Others
Protein ID: WP_130650702.1
Location: 3409723..3410004 (282 bp)
Type: Toxin
Protein ID: WP_130650703.1
Location: 3410014..3410310 (297 bp)
Type: Antitoxin
Protein ID: WP_130650704.1
Location: 3410442..3410654 (213 bp)
Type: Others
Protein ID: WP_130649563.1
Location: 3410651..3411058 (408 bp)
Type: Others
Protein ID: WP_130649562.1
Location: 3408500..3408769 (270 bp)
Type: Others
Protein ID: WP_130650699.1
Location: 3408771..3409097 (327 bp)
Type: Others
Protein ID: WP_130650700.1
Location: 3411082..3411678 (597 bp)
Type: Others
Protein ID: WP_130650705.1
Location: 3412137..3412802 (666 bp)
Type: Others
Protein ID: WP_205745312.1
Location: 3412882..3414180 (1299 bp)
Type: Others
Protein ID: WP_130650707.1
Location: 3414177..3414887 (711 bp)
Type: Others
Protein ID: WP_130650708.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ELR47_RS154603407049..3407363+315WP_130648066.1transposase-
ELR47_RS154653407360..3408265+906WP_165404127.1IS3 family transposase-
ELR47_RS154703408500..3408769-270WP_130650699.1hypothetical protein-
ELR47_RS154753408771..3409097-327WP_130650700.1hypothetical protein-
ELR47_RS154803409086..3409331+246WP_130650701.1addiction module protein-
ELR47_RS154853409328..3409633+306WP_130650702.1type II toxin-antitoxin system RelE/ParE family toxin-
ELR47_RS154903409723..3410004+282WP_130650703.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ELR47_RS154953410014..3410310+297WP_130650704.1HigA family addiction module antidote proteinAntitoxin
ELR47_RS155003410442..3410654+213WP_130649563.1type II toxin-antitoxin system HicA family toxin-
ELR47_RS155053410651..3411058+408WP_130649562.1helix-turn-helix domain-containing protein-
ELR47_RS155103411082..3411678-597WP_130650705.1MFS transporter-
ELR47_RS155153412137..3412802-666WP_205745312.1NAD(P)H-binding protein-
ELR47_RS155203412882..3414180-1299WP_130650707.1amidase-
ELR47_RS155253414177..3414887-711WP_130650708.1carbon monoxide dehydrogenase subunit G-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--3384147..341339329246


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-79)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11141.73 Da        Isoelectric Point: 10.5256

>T119444 WP_130650703.1 NZ_CP036250:3409723-3410004 [Egicoccus halophilus]
MIRSFRDRDTERLAARQRVKRWPPELSKAALRKLRMLDAAEELIDLRAPPGNRLERLKGDRQGQHSIRINDQWRICFRWE
AGNAYDVEIVDYH

Download         Length: 282 bp

>T119444 NZ_CP036250:3409723-3410004 [Egicoccus halophilus]
ATGATCCGCAGCTTCCGCGACCGCGACACCGAACGCCTCGCTGCGCGGCAGCGGGTCAAGAGGTGGCCTCCTGAACTGAG
CAAGGCTGCCCTGCGCAAGCTGCGGATGCTCGATGCCGCCGAGGAACTCATCGACCTGCGCGCCCCTCCCGGCAACCGAC
TCGAACGGCTGAAGGGCGACCGGCAAGGACAGCACTCCATCCGCATCAACGACCAGTGGCGCATCTGCTTCCGATGGGAG
GCCGGCAACGCCTACGACGTCGAGATCGTGGACTACCACTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11081.66 Da        Isoelectric Point: 7.3194

>AT119444 WP_130650704.1 NZ_CP036250:3410014-3410310 [Egicoccus halophilus]
METKLPPVHPGEVLLEEFLAPTGLSQYRLAKDISVPPRRINEIVHGKRAVTADTALRLARRLGTTPRFWLNLQAQYDLDV
ETDRLGDRLDREVAAHAN

Download         Length: 297 bp

>AT119444 NZ_CP036250:3410014-3410310 [Egicoccus halophilus]
ATGGAGACGAAGCTCCCACCCGTCCACCCCGGCGAAGTGCTCCTCGAGGAGTTTCTCGCACCGACCGGGCTGTCGCAGTA
CCGGCTCGCCAAGGACATCAGCGTCCCACCCCGTCGCATCAACGAAATCGTGCACGGCAAGCGCGCCGTCACCGCTGACA
CCGCCCTACGGCTAGCCCGCCGCCTCGGCACCACCCCGCGGTTCTGGCTCAACCTTCAGGCCCAGTACGACCTCGACGTC
GAAACCGACCGCCTCGGCGACCGACTCGACCGCGAGGTCGCCGCGCACGCCAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
No matching records found

References