Detailed information of TA system TA119440

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2847383..2847723
• Replicon: chromosome
• Accession: NZ_CP036249
• Organism: Enterococcus faecalis R712

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A2P6B8G0
• Locus tag: EYB36_RS15185
• Protein ID: WP_002354873.1
• Coordinates: 2847383..2847535 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2847468..2847723 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYB36_RS15165	2843611..2844249	-	639	WP_024041656.1	lytic polysaccharide monooxygenase	-
EYB36_RS15175	2844934..2846550	+	1617	WP_002368505.1	phosphatase PAP2/LCP family protein	-
EYB36_RS15180	2846765..2846962	+	198	WP_002368507.1	putative holin-like toxin	-
-	2846895..2847081	-	187	NuclAT_7	-	-
-	2847112..2847279	-	168	NuclAT_13	-	-
-	2847134..2847279	-	146	NuclAT_9	-	-
EYB36_RS15185	2847383..2847535	+	153	WP_002354873.1	putative holin-like toxin	Toxin
-	2847468..2847723	-	256	NuclAT_6	-	Antitoxin
-	2847509..2847725	-	217	NuclAT_12	-	-
-	2847675..2847724	+	50	NuclAT_15	-	-
EYB36_RS15770	2847725..2850784	-	3060	WP_002368508.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (17-50)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5651.89 Da
• Isoelectric Point: 10.9857

>T119440 WP_002354873.1 NZ_CP036249:2847383-2847535 [Enterococcus faecalis R712]
VVRMSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 153 bp

>T119440 NZ_CP036249:2847383-2847535 [Enterococcus faecalis R712]
GTGGTGCGTATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACAATTCT
TGGGTTTGGTATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 256 bp

>AT119440 NZ_CP036249:c2847723-2847468 [Enterococcus faecalis R712]
ATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATAAT
AGCATTGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACTTTTTGGATTATTTAA
AAATAACCGTACTGGTCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGTGCAATCAAAGCA
ATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A2P6B8G0

Antitoxin