Detailed information of TA system TA119431

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2772407..2772667
• Replicon: chromosome
• Accession: NZ_CP036249
• Organism: Enterococcus faecalis R712

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: EYB36_RS14830
• Protein ID: WP_002392696.1
• Coordinates: 2772524..2772667 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2772407..2772591 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EYB36_RS14815	2767969..2768682	-	714	WP_002354877.1	trehalose operon repressor	-
EYB36_RS14820	2768943..2771687	+	2745	WP_002368465.1	glycoside hydrolase family 65 protein	-
EYB36_RS14825	2771702..2772352	+	651	WP_002368467.1	beta-phosphoglucomutase	-
-	2772407..2772591	+	185	NuclAT_8	-	Antitoxin
-	2772421..2772550	+	130	NuclAT_14	-	-
EYB36_RS14830	2772524..2772667	-	144	WP_002392696.1	putative holin-like toxin	Toxin
EYB36_RS14835	2772899..2773870	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
EYB36_RS14840	2774045..2774482	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
EYB36_RS14845	2774615..2775169	-	555	WP_002354869.1	septum formation protein Maf	-
EYB36_RS14850	2775194..2777326	-	2133	WP_002368469.1	DNA mismatch repair endonuclease MutL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T119431 WP_002392696.1 NZ_CP036249:c2772667-2772524 [Enterococcus faecalis R712]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T119431 NZ_CP036249:c2772667-2772524 [Enterococcus faecalis R712]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 185 bp

>AT119431 NZ_CP036249:2772407-2772591 [Enterococcus faecalis R712]
TGCTAGAATGTAGATGAAAAGAGAGAGATGCGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATTTT
GTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin