Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1417860..1418081 Replicon chromosome
Accession NZ_CP036245
Organism Escherichia coli strain S65EC

Toxin (Protein)


Gene name ldrD Uniprot ID A0A1U9U3P9
Locus tag S65EC_RS08125 Protein ID WP_001531632.1
Coordinates 1417860..1417967 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1418015..1418081 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
S65EC_RS08100 1413704..1414786 + 1083 WP_000804726.1 peptide chain release factor 1 -
S65EC_RS08105 1414786..1415619 + 834 WP_000456450.1 peptide chain release factor N(5)-glutamine methyltransferase -
S65EC_RS08110 1415616..1416008 + 393 WP_000200375.1 invasion regulator SirB2 -
S65EC_RS08115 1416012..1416821 + 810 WP_001257044.1 invasion regulator SirB1 -
S65EC_RS08120 1416857..1417711 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
S65EC_RS08125 1417860..1417967 - 108 WP_001531632.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 1418015..1418081 + 67 NuclAT_10 - Antitoxin
- 1418015..1418081 + 67 NuclAT_10 - Antitoxin
- 1418015..1418081 + 67 NuclAT_10 - Antitoxin
- 1418015..1418081 + 67 NuclAT_10 - Antitoxin
- 1418015..1418081 + 67 NuclAT_5 - Antitoxin
- 1418015..1418081 + 67 NuclAT_5 - Antitoxin
- 1418015..1418081 + 67 NuclAT_5 - Antitoxin
- 1418015..1418081 + 67 NuclAT_5 - Antitoxin
- 1418015..1418081 + 67 NuclAT_6 - Antitoxin
- 1418015..1418081 + 67 NuclAT_6 - Antitoxin
- 1418015..1418081 + 67 NuclAT_6 - Antitoxin
- 1418015..1418081 + 67 NuclAT_6 - Antitoxin
- 1418015..1418081 + 67 NuclAT_7 - Antitoxin
- 1418015..1418081 + 67 NuclAT_7 - Antitoxin
- 1418015..1418081 + 67 NuclAT_7 - Antitoxin
- 1418015..1418081 + 67 NuclAT_7 - Antitoxin
- 1418015..1418081 + 67 NuclAT_8 - Antitoxin
- 1418015..1418081 + 67 NuclAT_8 - Antitoxin
- 1418015..1418081 + 67 NuclAT_8 - Antitoxin
- 1418015..1418081 + 67 NuclAT_8 - Antitoxin
- 1418015..1418081 + 67 NuclAT_9 - Antitoxin
- 1418015..1418081 + 67 NuclAT_9 - Antitoxin
- 1418015..1418081 + 67 NuclAT_9 - Antitoxin
- 1418015..1418081 + 67 NuclAT_9 - Antitoxin
- 1418017..1418080 + 64 NuclAT_12 - -
- 1418017..1418080 + 64 NuclAT_12 - -
- 1418017..1418080 + 64 NuclAT_12 - -
- 1418017..1418080 + 64 NuclAT_12 - -
- 1418017..1418080 + 64 NuclAT_13 - -
- 1418017..1418080 + 64 NuclAT_13 - -
- 1418017..1418080 + 64 NuclAT_13 - -
- 1418017..1418080 + 64 NuclAT_13 - -
- 1418017..1418080 + 64 NuclAT_14 - -
- 1418017..1418080 + 64 NuclAT_14 - -
- 1418017..1418080 + 64 NuclAT_14 - -
- 1418017..1418080 + 64 NuclAT_14 - -
- 1418017..1418080 + 64 NuclAT_15 - -
- 1418017..1418080 + 64 NuclAT_15 - -
- 1418017..1418080 + 64 NuclAT_15 - -
- 1418017..1418080 + 64 NuclAT_15 - -
- 1418017..1418080 + 64 NuclAT_16 - -
- 1418017..1418080 + 64 NuclAT_16 - -
- 1418017..1418080 + 64 NuclAT_16 - -
- 1418017..1418080 + 64 NuclAT_16 - -
- 1418017..1418080 + 64 NuclAT_17 - -
- 1418017..1418080 + 64 NuclAT_17 - -
- 1418017..1418080 + 64 NuclAT_17 - -
- 1418017..1418080 + 64 NuclAT_17 - -
- 1418017..1418082 + 66 NuclAT_18 - -
- 1418017..1418082 + 66 NuclAT_18 - -
- 1418017..1418082 + 66 NuclAT_18 - -
- 1418017..1418082 + 66 NuclAT_18 - -
- 1418017..1418082 + 66 NuclAT_19 - -
- 1418017..1418082 + 66 NuclAT_19 - -
- 1418017..1418082 + 66 NuclAT_19 - -
- 1418017..1418082 + 66 NuclAT_19 - -
- 1418017..1418082 + 66 NuclAT_20 - -
- 1418017..1418082 + 66 NuclAT_20 - -
- 1418017..1418082 + 66 NuclAT_20 - -
- 1418017..1418082 + 66 NuclAT_20 - -
- 1418017..1418082 + 66 NuclAT_21 - -
- 1418017..1418082 + 66 NuclAT_21 - -
- 1418017..1418082 + 66 NuclAT_21 - -
- 1418017..1418082 + 66 NuclAT_21 - -
- 1418017..1418082 + 66 NuclAT_22 - -
- 1418017..1418082 + 66 NuclAT_22 - -
- 1418017..1418082 + 66 NuclAT_22 - -
- 1418017..1418082 + 66 NuclAT_22 - -
- 1418017..1418082 + 66 NuclAT_23 - -
- 1418017..1418082 + 66 NuclAT_23 - -
- 1418017..1418082 + 66 NuclAT_23 - -
- 1418017..1418082 + 66 NuclAT_23 - -
S65EC_RS08130 1418372..1419472 - 1101 WP_130647902.1 sodium-potassium/proton antiporter ChaA -
S65EC_RS08135 1419742..1419981 + 240 WP_000120702.1 putative cation transport regulator ChaB -
S65EC_RS08140 1420130..1420825 + 696 WP_001295621.1 glutathione-specific gamma-glutamylcyclotransferase -
S65EC_RS08145 1420869..1421222 - 354 WP_001169659.1 DsrE/F sulfur relay family protein YchN -
S65EC_RS08150 1421407..1422801 + 1395 WP_000086187.1 inverse autotransporter invasin YchO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4040.89 Da        Isoelectric Point: 12.5163

>T119396 WP_001531632.1 NZ_CP036245:c1417967-1417860 [Escherichia coli]
MTLAQFAMIFWHNLAAPILAGIITAVIVSWWRNRK

Download         Length: 108 bp

>T119396 NZ_CP036245:c1417967-1417860 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 67 bp

>AT119396 NZ_CP036245:1418015-1418081 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9U3P9

Antitoxin

Download structure file

References