119123

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 5492022..5492676 Replicon chromosome
Accession NZ_CP035952
Organism Pseudomonas sp. SNU WT1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EXN22_RS25285 Protein ID WP_130266584.1
Coordinates 5492022..5492360 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EXN22_RS25290 Protein ID WP_130266585.1
Coordinates 5492362..5492676 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXN22_RS25260 5488863..5489267 - 405 WP_130266579.1 type II toxin-antitoxin system HicB family antitoxin -
EXN22_RS25265 5489332..5489514 - 183 WP_130266580.1 type II toxin-antitoxin system HicA family toxin -
EXN22_RS25270 5489649..5490446 - 798 WP_130266581.1 helix-turn-helix transcriptional regulator -
EXN22_RS25275 5490531..5491349 + 819 WP_130266582.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -
EXN22_RS25280 5491442..5491903 + 462 WP_130266583.1 Lrp/AsnC family transcriptional regulator -
EXN22_RS25285 5492022..5492360 + 339 WP_130266584.1 toxin Toxin
EXN22_RS25290 5492362..5492676 + 315 WP_130266585.1 transcriptional regulator Antitoxin
EXN22_RS25295 5492835..5494517 + 1683 WP_130266586.1 NAD(P)/FAD-dependent oxidoreductase -
EXN22_RS25300 5494531..5495328 + 798 WP_130266587.1 carbon-nitrogen hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-100)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13205.02 Da        Isoelectric Point: 8.0138

>T119123 WP_130266584.1 NZ_CP035952:5492022-5492360 [Pseudomonas sp. SNU WT1]
MEALFVELPAFARYRCDYLDDQAFRALQFILLLNPHADSVIQGTGGLRKMRFADEQRHKGKRGGTRVIYYWWNSGQQFWL
FTLYGKDQQDDLSAAQRQLLKQMLDQEIEART

Download         Length: 339 bp

>T119123 NZ_CP035952:5492022-5492360 [Pseudomonas sp. SNU WT1]
ATGGAAGCCCTTTTTGTCGAACTACCGGCCTTTGCTCGCTACCGTTGCGACTACCTGGATGACCAGGCTTTCAGGGCCTT
GCAGTTCATCCTGCTGCTCAACCCCCACGCGGACTCGGTCATTCAGGGCACAGGCGGCCTGCGCAAGATGCGCTTCGCCG
ATGAACAGCGGCATAAGGGAAAACGCGGCGGCACGCGGGTGATCTACTACTGGTGGAACAGTGGTCAGCAGTTCTGGTTG
TTCACCTTGTATGGCAAGGATCAGCAAGACGACCTGAGCGCGGCTCAACGCCAGTTGCTCAAACAGATGCTCGATCAGGA
AATCGAGGCGAGGACATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12061.91 Da        Isoelectric Point: 7.1679

>AT119123 WP_130266585.1 NZ_CP035952:5492362-5492676 [Pseudomonas sp. SNU WT1]
MTRNIFSELNEGFDALAQERQGKLTLRSHKLQLTELMDVCAEELVAIRERLNMSRAVFAMYLRTNVRTLENWEQGRARPN
AQAMTLIRLVEKYPETVEHLAALT

Download         Length: 315 bp

>AT119123 NZ_CP035952:5492362-5492676 [Pseudomonas sp. SNU WT1]
ATGACGCGCAATATTTTTTCCGAACTGAACGAAGGCTTCGATGCCCTTGCCCAGGAGCGTCAAGGCAAATTGACCCTGCG
CTCGCACAAGCTGCAGCTCACCGAGCTGATGGACGTTTGCGCCGAAGAGCTCGTAGCGATTCGCGAACGGCTCAACATGT
CCCGTGCGGTATTTGCCATGTACCTGCGCACCAACGTTCGTACGCTGGAAAACTGGGAACAGGGAAGAGCTCGCCCCAAT
GCCCAGGCAATGACCTTGATTCGATTGGTGGAAAAATACCCGGAAACCGTCGAGCATTTGGCTGCACTCACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References