Detailed information of TA system TA119112

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3883838..3884096
• Replicon: chromosome
• Accession: NZ_CP035944
• Organism: Escherichia coli strain AR24.2b

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: EXT04_RS18920
• Protein ID: WP_000935262.1
• Coordinates: 3883887..3884096 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3883838..3883895 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXT04_RS22845	3878892..3879668	+	777	WP_166666977.1	fimbria/pilus outer membrane usher protein	-
EXT04_RS22850	3879684..3879905	+	222	Protein_3658	fimbria/pilus outer membrane usher protein	-
EXT04_RS18905	3880409..3881188	+	780	WP_166666976.1	hypothetical protein	-
EXT04_RS18910	3881227..3882126	-	900	WP_001300855.1	transcriptional activator NhaR	-
EXT04_RS18915	3882192..3883358	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	3883838..3883895	-	58	-	-	Antitoxin
EXT04_RS18920	3883887..3884096	+	210	WP_000935262.1	type I toxin-antitoxin system Hok family toxin	Toxin
EXT04_RS18925	3884200..3885330	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
EXT04_RS18930	3885419..3887335	-	1917	WP_000516131.1	molecular chaperone DnaK	-
EXT04_RS18935	3887712..3888116	+	405	WP_000843559.1	DUF2541 family protein	-
EXT04_RS18940	3888142..3888855	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7742.28 Da
• Isoelectric Point: 9.3680

>T119112 WP_000935262.1 NZ_CP035944:3883887-3884096 [Escherichia coli]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T119112 NZ_CP035944:3883887-3884096 [Escherichia coli]
ATGCTGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT119112 NZ_CP035944:c3883895-3883838 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin