Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 7292..7877 Replicon plasmid p2_060092
Accession NZ_CP035937
Organism Acinetobacter cumulans strain WCHAc060092

Toxin (Protein)


Gene name higB Uniprot ID N9CJF7
Locus tag C9E88_RS17280 Protein ID WP_000897307.1
Coordinates 7557..7877 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C9E88_RS17275 Protein ID WP_000369781.1
Coordinates 7292..7564 (-) Length 91 a.a.

Genomic Context

C9E88_RS17245C9E88_RS17250C9E88_RS17260C9E88_RS17290C9E88_RS17255C9E88_RS17265C9E88_RS17270C9E88_RS17275C9E88_RS17280C9E88_RS17285C9E88_RS17650C9E88_RS17295C9E88_RS17300
Location: 2374..2730 (357 bp)
Type: Others
Protein ID: WP_004967307.1
Location: 2723..3025 (303 bp)
Type: Others
Protein ID: WP_001140620.1
Location: 3583..4194 (612 bp)
Type: Others
Protein ID: WP_015060246.1
Location: 8743..9930 (1188 bp)
Type: Others
Protein ID: WP_004856455.1
Location: 3107..3382 (276 bp)
Type: Others
Protein ID: WP_004967304.1
Location: 4384..5268 (885 bp)
Type: Others
Protein ID: WP_000155092.1
Location: 5324..6799 (1476 bp)
Type: Others
Protein ID: WP_000052512.1
Location: 7292..7564 (273 bp)
Type: Antitoxin
Protein ID: WP_000369781.1
Location: 7557..7877 (321 bp)
Type: Toxin
Protein ID: WP_000897307.1
Location: 8036..8677 (642 bp)
Type: Others
Protein ID: WP_004787586.1
Location: 10154..10297 (144 bp)
Type: Others
Protein ID: WP_167514224.1
Location: 10310..10864 (555 bp)
Type: Others
Protein ID: WP_068975321.1
Location: 10868..11812 (945 bp)
Type: Others
Protein ID: WP_068912167.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C9E88_RS172452374..2730+357WP_004967307.1type II toxin-antitoxin system RelE/ParE family toxin-
C9E88_RS172502723..3025+303WP_001140620.1XRE family transcriptional regulator-
C9E88_RS172553107..3382-276WP_004967304.1hypothetical protein-
C9E88_RS172603583..4194+612WP_015060246.1recombinase family protein-
C9E88_RS172654384..5268-885WP_000155092.1Mph(E) family macrolide 2'-phosphotransferase-
C9E88_RS172705324..6799-1476WP_000052512.1ABC-F type ribosomal protection protein Msr(E)-
C9E88_RS172757292..7564-273WP_000369781.1helix-turn-helix domain-containing proteinAntitoxin
C9E88_RS172807557..7877-321WP_000897307.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C9E88_RS172858036..8677-642WP_004787586.1TetR/AcrR family transcriptional regulator C-terminal domain-containing protein-
C9E88_RS172908743..9930+1188WP_004856455.1tetracycline efflux MFS transporter Tet(39)-
C9E88_RS1765010154..10297-144WP_167514224.1hypothetical protein-
C9E88_RS1729510310..10864-555WP_068975321.1helix-turn-helix domain-containing protein-
C9E88_RS1730010868..11812-945WP_068912167.1replication initiation protein RepM-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidaph(3'')-Ib / aph(6)-Id / mph(E) / msr(E) / tet(39) / sul2-1..1876118761
-insideIS/Tnaph(3'')-Ib / aph(6)-Id / mph(E) / msr(E) / tet(39)-28..99309902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12187.95 Da        Isoelectric Point: 7.1639

>T119094 WP_000897307.1 NZ_CP035937:c7877-7557 [Acinetobacter cumulans]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG

Download         Length: 321 bp

>T119094 NZ_CP035937:c7877-7557 [Acinetobacter cumulans]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGCA
AGATCTTTTGGTACAGCCTGATAGAGGTGACCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGGAAAAGTGGTGGGATACGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATCTTTTTCTTAGTGGCTTAT
CCAAAATCAGTAAAAGATAATTTAACAGATAAGGAAACCGCCATTCTGCACCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10149.61 Da        Isoelectric Point: 8.6582

>AT119094 WP_000369781.1 NZ_CP035937:c7564-7292 [Acinetobacter cumulans]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp

>AT119094 NZ_CP035937:c7564-7292 [Acinetobacter cumulans]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAAGTTAAAGCAAG
CCGAGTTACAGAACTCGAATTGCCTGATATTAAAGAAGTACGTGAAAAAACTGGCTTGAGCCAAAATGAATTTGCTGCAC
GTCTACATATTAGCCCCCGTACCCTGCAAAATTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTGATT
CGAATTTTAGATGCTCACCCAAGCCTTATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0A8TMZ3

Antitoxin

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Source
ID
Structure
No matching records found

References