Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2374..3025 Replicon plasmid p2_060092
Accession NZ_CP035937
Organism Acinetobacter cumulans strain WCHAc060092

Toxin (Protein)


Gene name higB Uniprot ID N9BC17
Locus tag C9E88_RS17245 Protein ID WP_004967307.1
Coordinates 2374..2730 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag C9E88_RS17250 Protein ID WP_001140620.1
Coordinates 2723..3025 (+) Length 101 a.a.

Genomic Context

C9E88_RS17230C9E88_RS17235C9E88_RS17245C9E88_RS17250C9E88_RS17260C9E88_RS17255C9E88_RS17265C9E88_RS17270C9E88_RS17275C9E88_RS17280
Location: 514..1317 (804 bp)
Type: Others
Protein ID: WP_001082319.1
Location: 1317..2153 (837 bp)
Type: Others
Protein ID: WP_000480968.1
Location: 2374..2730 (357 bp)
Type: Toxin
Protein ID: WP_004967307.1
Location: 2723..3025 (303 bp)
Type: Antitoxin
Protein ID: WP_001140620.1
Location: 3583..4194 (612 bp)
Type: Others
Protein ID: WP_015060246.1
Location: 3107..3382 (276 bp)
Type: Others
Protein ID: WP_004967304.1
Location: 4384..5268 (885 bp)
Type: Others
Protein ID: WP_000155092.1
Location: 5324..6799 (1476 bp)
Type: Others
Protein ID: WP_000052512.1
Location: 7292..7564 (273 bp)
Type: Others
Protein ID: WP_000369781.1
Location: 7557..7877 (321 bp)
Type: Others
Protein ID: WP_000897307.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
C9E88_RS17230514..1317+804WP_001082319.1aminoglycoside O-phosphotransferase APH(3'')-Ib-
C9E88_RS172351317..2153+837WP_000480968.1aminoglycoside O-phosphotransferase APH(6)-Id-
C9E88_RS172452374..2730+357WP_004967307.1type II toxin-antitoxin system RelE/ParE family toxinToxin
C9E88_RS172502723..3025+303WP_001140620.1XRE family transcriptional regulatorAntitoxin
C9E88_RS172553107..3382-276WP_004967304.1hypothetical protein-
C9E88_RS172603583..4194+612WP_015060246.1recombinase family protein-
C9E88_RS172654384..5268-885WP_000155092.1Mph(E) family macrolide 2'-phosphotransferase-
C9E88_RS172705324..6799-1476WP_000052512.1ABC-F type ribosomal protection protein Msr(E)-
C9E88_RS172757292..7564-273WP_000369781.1helix-turn-helix domain-containing protein-
C9E88_RS172807557..7877-321WP_000897307.1type II toxin-antitoxin system RelE/ParE family toxin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidaph(3'')-Ib / aph(6)-Id / mph(E) / msr(E) / tet(39) / sul2-1..1876118761
-insideIS/Tnaph(3'')-Ib / aph(6)-Id / mph(E) / msr(E) / tet(39)-28..99309902


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13601.62 Da        Isoelectric Point: 6.4648

>T119093 WP_004967307.1 NZ_CP035937:2374-2730 [Acinetobacter cumulans]
MWIVITTDLFNEWLEQQDESTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIADKGSKKRFYKDMLDIADEQYQLHLTTLGDKSNG

Download         Length: 357 bp

>T119093 NZ_CP035937:2374-2730 [Acinetobacter cumulans]
ATGTGGATAGTCATTACGACAGATCTATTTAATGAATGGCTTGAACAGCAAGACGAATCAACACAAGAGAAGGTTCTGGC
TGCCCTAGTTGTTCTACAGCAGCAAGGACCAAGTTTAGGCCGCCCTTTAGTAGATACTGTCTATGACTCTAAATTTACCA
ACATGAAAGAGCTTCGTGTTCAACATCGAGGTAAACCACTGAGAGCTTTCTTCGCATTTGATCCTTTACGACAGGCTATT
GTTCTATGTATTGCTGATAAAGGCAGTAAAAAGCGTTTTTATAAAGACATGCTGGATATTGCAGATGAACAATACCAACT
TCATCTCACCACCCTAGGAGATAAATCTAATGGCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11227.02 Da        Isoelectric Point: 6.4759

>AT119093 WP_001140620.1 NZ_CP035937:2723-3025 [Acinetobacter cumulans]
MAKTLQELLASRSPESQARIQKMADELLLENQLHLIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT119093 NZ_CP035937:2723-3025 [Acinetobacter cumulans]
ATGGCTAAGACTCTGCAAGAATTGTTAGCTAGCCGCTCTCCAGAGAGCCAAGCCCGTATTCAAAAAATGGCAGATGAATT
ACTGCTAGAAAATCAGCTTCATCTTATTCGTGAAGAACTTGAAATCTCTCAAAAGGAACTTGCTGAAACTTTGGGAATAA
AACAGCCATCGCTTTCAGCAATAGAAAATCGTGGCAATGATCTTAAGATTTCAACCATGAAAAAGTATGTTGAGGCAATG
GGCGGGAAGCTCCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGATTCAATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7T4TW67

Antitoxin

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Source
ID
Structure
No matching records found

References