Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 772527..773032 Replicon chromosome
Accession NZ_CP035926
Organism Arcobacter thereius LMG 24486

Toxin (Protein)


Gene name yoeB Uniprot ID A0A494T483
Locus tag ATH_RS04020 Protein ID WP_066157207.1
Coordinates 772527..772793 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1V9VC04
Locus tag ATH_RS04025 Protein ID WP_066157209.1
Coordinates 772787..773032 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ATH_RS03995 767699..768292 - 594 WP_066183545.1 FAD-dependent oxidoreductase -
ATH_RS04000 768311..769009 - 699 WP_066183547.1 alpha/beta hydrolase -
ATH_RS04005 769144..769341 + 198 WP_066183551.1 DUF2892 domain-containing protein -
ATH_RS04010 769351..770652 - 1302 WP_066183554.1 succinylglutamate desuccinylase/aspartoacylase family protein -
ATH_RS04015 770817..772517 + 1701 WP_066390528.1 YdiU family protein -
ATH_RS04020 772527..772793 - 267 WP_066157207.1 Txe/YoeB family addiction module toxin Toxin
ATH_RS04025 772787..773032 - 246 WP_066157209.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ATH_RS04030 773241..773945 - 705 WP_066183559.1 hypothetical protein -
ATH_RS04035 774069..775604 - 1536 WP_066183560.1 glutamine-hydrolyzing GMP synthase -
ATH_RS04040 775667..777115 - 1449 WP_066183561.1 FAD-binding protein -
ATH_RS04045 777199..777618 + 420 WP_066183564.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(24-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10229.96 Da        Isoelectric Point: 9.9946

>T119070 WP_066157207.1 NZ_CP035926:c772793-772527 [Arcobacter thereius LMG 24486]
MVNYKLVYTKQAGKDAKKLSNSGLKSKALELLEIISLNPYQNPPPYEKLIGDLNSAISRRINIQHRLVYEVLEDIKTIKV
IRMWSHYE

Download         Length: 267 bp

>T119070 NZ_CP035926:c772793-772527 [Arcobacter thereius LMG 24486]
ATGGTAAACTATAAACTTGTTTATACTAAACAAGCTGGAAAAGATGCCAAGAAATTATCTAATTCAGGCTTAAAATCAAA
GGCTTTGGAATTATTAGAGATAATTTCTTTAAATCCATATCAAAATCCTCCACCTTATGAAAAACTAATTGGTGATTTAA
ATAGTGCAATATCAAGAAGAATAAATATTCAACACAGATTAGTTTATGAAGTTTTAGAAGATATTAAAACTATAAAAGTG
ATACGAATGTGGTCACATTATGAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9284.61 Da        Isoelectric Point: 4.2550

>AT119070 WP_066157209.1 NZ_CP035926:c773032-772787 [Arcobacter thereius LMG 24486]
MTKVMTVSQVRADIYNIIDETALTHEPILITGKRTNAVMLSQEDWNAIQETLYLTSIPNMRESIIKGLNTSIEDCDKELE
W

Download         Length: 246 bp

>AT119070 NZ_CP035926:c773032-772787 [Arcobacter thereius LMG 24486]
ATGACGAAAGTTATGACAGTTAGTCAAGTTCGAGCAGATATTTATAATATTATTGATGAAACAGCATTAACACATGAACC
AATACTTATAACTGGTAAAAGAACAAATGCTGTTATGTTATCTCAAGAAGATTGGAATGCCATCCAAGAGACTTTATATC
TAACATCAATTCCAAATATGAGAGAATCTATAATTAAAGGATTAAATACATCTATTGAAGATTGTGATAAAGAGTTAGAA
TGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A494T483

Antitoxin

Source ID Structure
AlphaFold DB A0A1V9VC04

References