Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1117854..1118547 Replicon chromosome
Accession NZ_CP035874
Organism Escherichia coli strain B2C

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag EW998_RS05410 Protein ID WP_000415584.1
Coordinates 1117854..1118150 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag EW998_RS05415 Protein ID WP_000650107.1
Coordinates 1118152..1118547 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EW998_RS05375 (1112942) 1112942..1113256 - 315 WP_000958598.1 putative quinol monooxygenase -
EW998_RS05380 (1113287) 1113287..1113868 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
EW998_RS05385 (1114187) 1114187..1114519 + 333 WP_000917686.1 DUF2645 family protein -
EW998_RS05390 (1114565) 1114565..1115914 - 1350 WP_000673409.1 quorum sensing histidine kinase QseC -
EW998_RS05395 (1115911) 1115911..1116570 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
EW998_RS05400 (1116722) 1116722..1117114 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
EW998_RS05405 (1117167) 1117167..1117649 + 483 WP_000183505.1 GyrI-like domain-containing protein -
EW998_RS05410 (1117854) 1117854..1118150 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
EW998_RS05415 (1118152) 1118152..1118547 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
EW998_RS05420 (1118680) 1118680..1120287 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
EW998_RS05425 (1120425) 1120425..1122683 + 2259 WP_001281866.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T118939 WP_000415584.1 NZ_CP035874:1117854-1118150 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T118939 NZ_CP035874:1117854-1118150 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT118939 WP_000650107.1 NZ_CP035874:1118152-1118547 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT118939 NZ_CP035874:1118152-1118547 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References