Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 60747..61001 | Replicon | plasmid pE275a_100 |
| Accession | NZ_CP035867 | ||
| Organism | Escherichia coli strain E275 a | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | A0A148HBD8 |
| Locus tag | EXE34_RS25675 | Protein ID | WP_001336447.1 |
| Coordinates | 60747..60896 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 60945..61001 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXE34_RS25635 (56575) | 56575..57057 | - | 483 | WP_033879534.1 | hypothetical protein | - |
| EXE34_RS25640 (57059) | 57059..57325 | - | 267 | WP_000215180.1 | hypothetical protein | - |
| EXE34_RS25645 (57326) | 57326..57550 | - | 225 | WP_033879533.1 | hypothetical protein | - |
| EXE34_RS25650 (57596) | 57596..57874 | - | 279 | WP_249530679.1 | type II toxin-antitoxin system toxin YacB | - |
| EXE34_RS25655 (57874) | 57874..58143 | - | 270 | WP_000079935.1 | type II toxin-antitoxin system antitoxin YacA | - |
| EXE34_RS25660 (59056) | 59056..59913 | - | 858 | WP_000130964.1 | incFII family plasmid replication initiator RepA | - |
| EXE34_RS26780 (59906) | 59906..59953 | - | 48 | WP_234812421.1 | hypothetical protein | - |
| EXE34_RS26785 (59944) | 59944..60177 | + | 234 | WP_231819095.1 | replication protein RepA | - |
| EXE34_RS25670 (60203) | 60203..60463 | - | 261 | WP_000083817.1 | replication regulatory protein RepA | - |
| EXE34_RS25675 (60747) | 60747..60896 | - | 150 | WP_001336447.1 | Hok/Gef family protein | Toxin |
| - (60945) | 60945..61001 | + | 57 | NuclAT_1 | - | Antitoxin |
| - (60945) | 60945..61001 | + | 57 | NuclAT_1 | - | Antitoxin |
| - (60945) | 60945..61001 | + | 57 | NuclAT_1 | - | Antitoxin |
| - (60945) | 60945..61001 | + | 57 | NuclAT_1 | - | Antitoxin |
| EXE34_RS25680 (61245) | 61245..61427 | + | 183 | WP_001393357.1 | hypothetical protein | - |
| EXE34_RS25685 (61652) | 61652..62383 | - | 732 | WP_001071488.1 | type-F conjugative transfer system pilin acetylase TraX | - |
| EXE34_RS25690 (62380) | 62380..62946 | - | 567 | WP_074511253.1 | DUF2726 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | etpA / etpB | 1..100141 | 100141 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5572.69 Da Isoelectric Point: 8.7678
>T118906 WP_001336447.1 NZ_CP035867:c60896-60747 [Escherichia coli]
MTKYTLIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYTLIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T118906 NZ_CP035867:c60896-60747 [Escherichia coli]
ATGACGAAATATACCCTTATTGGGTTGCTCGCCGTGTGTGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTTTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATACCCTTATTGGGTTGCTCGCCGTGTGTGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAACTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTTTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 57 bp
>AT118906 NZ_CP035867:60945-61001 [Escherichia coli]
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
GTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
