Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3892859..3893552 Replicon chromosome
Accession NZ_CP035865
Organism Escherichia coli strain E275 a

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag EXE34_RS19150 Protein ID WP_000415584.1
Coordinates 3893256..3893552 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag EXE34_RS19145 Protein ID WP_000650107.1
Coordinates 3892859..3893254 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXE34_RS19135 (3888723) 3888723..3890981 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
EXE34_RS19140 (3891119) 3891119..3892726 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
EXE34_RS19145 (3892859) 3892859..3893254 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
EXE34_RS19150 (3893256) 3893256..3893552 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
EXE34_RS19155 (3893757) 3893757..3894239 - 483 WP_000183505.1 GyrI-like domain-containing protein -
EXE34_RS19160 (3894292) 3894292..3894684 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
EXE34_RS19165 (3894836) 3894836..3895495 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
EXE34_RS19170 (3895492) 3895492..3896841 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
EXE34_RS19175 (3896887) 3896887..3897219 - 333 WP_000917684.1 DUF2645 family protein -
EXE34_RS19180 (3897538) 3897538..3898119 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
EXE34_RS19185 (3898150) 3898150..3898464 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T118897 WP_000415584.1 NZ_CP035865:c3893552-3893256 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T118897 NZ_CP035865:c3893552-3893256 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT118897 WP_000650107.1 NZ_CP035865:c3893254-3892859 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT118897 NZ_CP035865:c3893254-3892859 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References