Detailed information of TA system TA118892

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 2368927..2369298
• Replicon: chromosome
• Accession: NZ_CP035865
• Organism: Escherichia coli strain E275 a

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A7W3G0W6
• Locus tag: EXE34_RS11595
• Protein ID: WP_072130784.1
• Coordinates: 2368927..2369121 (+)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2369120..2369298 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXE34_RS11565 (2363956)	2363956..2364108	+	153	WP_001594003.1	DUF1391 family protein	-
EXE34_RS11570 (2364529)	2364529..2364750	+	222	WP_000560220.1	killing protein KilR	-
EXE34_RS11575 (2364744)	2364744..2364920	+	177	WP_001594002.1	YdaE family protein	-
EXE34_RS11580 (2364995)	2364995..2365270	+	276	WP_001594001.1	phage protein	-
EXE34_RS11585 (2365369)	2365369..2368044	+	2676	WP_001718192.1	exodeoxyribonuclease VIII	-
EXE34_RS11590 (2368037)	2368037..2368870	+	834	WP_000166322.1	recombination protein RecT	-
EXE34_RS11595 (2368927)	2368927..2369121	+	195	WP_072130784.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
- (2369120)	2369120..2369298	-	179	NuclAT_1	-	Antitoxin
- (2369120)	2369120..2369298	-	179	NuclAT_1	-	Antitoxin
- (2369120)	2369120..2369298	-	179	NuclAT_1	-	Antitoxin
- (2369120)	2369120..2369298	-	179	NuclAT_1	-	Antitoxin
EXE34_RS11600 (2369114)	2369114..2369302	+	189	WP_216284996.1	DUF1187 family protein	-
EXE34_RS11605 (2369402)	2369402..2369617	+	216	WP_000079604.1	excisionase XisR	-
EXE34_RS11610 (2369619)	2369619..2370854	+	1236	WP_001593997.1	site-specific integrase	-
EXE34_RS11615 (2370906)	2370906..2371841	+	936	WP_001157376.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
EXE34_RS11620 (2371970)	2371970..2373343	-	1374	WP_000123737.1	ATP-dependent RNA helicase DbpA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2276436..2370854	94418

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7135.00 Da
• Isoelectric Point: 8.0115

>T118892 WP_072130784.1 NZ_CP035865:2368927-2369121 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV

Nucleotide

• Length: 195 bp

>T118892 NZ_CP035865:2368927-2369121 [Escherichia coli]
TTGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTGAAAGACATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCGCTCGAAAGATGGAATAAACGAA
CCACTGAAAATATTAATGGAGGCGTTCATGTATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT118892 NZ_CP035865:c2369298-2369120 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGATTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7W3G0W6

Antitoxin