Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1866497..1866999 Replicon chromosome
Accession NZ_CP035860
Organism Escherichia coli strain TD225-C4

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag EXA00_RS08880 Protein ID WP_000767829.1
Coordinates 1866745..1866999 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag EXA00_RS08875 Protein ID WP_001259255.1
Coordinates 1866497..1866748 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXA00_RS08850 (1861675) 1861675..1862742 - 1068 WP_000080085.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
EXA00_RS08855 (1862742) 1862742..1863812 - 1071 WP_107127196.1 histidinol-phosphate transaminase -
EXA00_RS08860 (1863809) 1863809..1865113 - 1305 WP_001515511.1 histidinol dehydrogenase -
EXA00_RS08865 (1865119) 1865119..1866018 - 900 WP_000131776.1 ATP phosphoribosyltransferase -
EXA00_RS08870 (1866164) 1866164..1866214 - 51 WP_001364200.1 his operon leader peptide -
EXA00_RS08875 (1866497) 1866497..1866748 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
EXA00_RS08880 (1866745) 1866745..1866999 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
EXA00_RS08885 (1867082) 1867082..1867906 + 825 WP_000754749.1 SDR family oxidoreductase -
EXA00_RS08890 (1867952) 1867952..1868881 + 930 WP_000803350.1 LysR substrate-binding domain-containing protein -
EXA00_RS08895 (1869096) 1869096..1869158 + 63 WP_010723108.1 membrane protein YoeI -
EXA00_RS08900 (1869148) 1869148..1870506 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
EXA00_RS08905 (1870685) 1870685..1871743 + 1059 WP_000492315.1 thiosulfate utilization transporter TsuA/YeeE -
EXA00_RS08910 (1871757) 1871757..1871984 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-84)

Antitoxin

(1-73)


Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T118860 WP_000767829.1 NZ_CP035860:1866745-1866999 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T118860 NZ_CP035860:1866745-1866999 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT118860 WP_001259255.1 NZ_CP035860:1866497-1866748 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT118860 NZ_CP035860:1866497-1866748 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q


Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References