Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2819754..2820447 Replicon chromosome
Accession NZ_CP035855
Organism Escherichia coli TW11681

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag EXE31_RS13760 Protein ID WP_000415584.1
Coordinates 2820151..2820447 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag EXE31_RS13755 Protein ID WP_000650107.1
Coordinates 2819754..2820149 (-) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXE31_RS13745 (2815618) 2815618..2817876 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
EXE31_RS13750 (2818014) 2818014..2819621 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
EXE31_RS13755 (2819754) 2819754..2820149 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
EXE31_RS13760 (2820151) 2820151..2820447 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
EXE31_RS13765 (2820652) 2820652..2821134 - 483 WP_000183494.1 GyrI-like domain-containing protein -
EXE31_RS13770 (2821187) 2821187..2821579 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
EXE31_RS13775 (2821731) 2821731..2822390 + 660 WP_001221503.1 quorum sensing response regulator transcription factor QseB -
EXE31_RS13780 (2822387) 2822387..2823736 + 1350 WP_000673355.1 quorum sensing histidine kinase QseC -
EXE31_RS13785 (2823782) 2823782..2824114 - 333 WP_000914690.1 DUF2645 family protein -
EXE31_RS26040 (2824121) 2824121..2824831 - 711 WP_000834029.1 hypothetical protein -
EXE31_RS26045 (2824834) 2824834..2825313 - 480 WP_000065332.1 Hcp family type VI secretion system effector -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T118839 WP_000415584.1 NZ_CP035855:c2820447-2820151 [Escherichia coli TW11681]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T118839 NZ_CP035855:c2820447-2820151 [Escherichia coli TW11681]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT118839 WP_000650107.1 NZ_CP035855:c2820149-2819754 [Escherichia coli TW11681]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT118839 NZ_CP035855:c2820149-2819754 [Escherichia coli TW11681]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACACAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3HI2


Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References