Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 54976..55240 | Replicon | plasmid pTW10590_71 |
| Accession | NZ_CP035854 | ||
| Organism | Escherichia coli strain TW10590 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | E6BRV3 |
| Locus tag | EXE32_RS26420 | Protein ID | WP_001303307.1 |
| Coordinates | 54976..55128 (-) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 55178..55240 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXE32_RS26390 (50232) | 50232..52400 | + | 2169 | WP_000698356.1 | DotA/TraY family protein | - |
| EXE32_RS26395 (52471) | 52471..53133 | + | 663 | WP_000644795.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| EXE32_RS26400 (53205) | 53205..53414 | - | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| EXE32_RS26405 (53816) | 53816..53992 | + | 177 | WP_001054898.1 | hypothetical protein | - |
| EXE32_RS26410 (54057) | 54057..54353 | - | 297 | WP_001275298.1 | DinQ-like type I toxin DqlB | - |
| EXE32_RS26415 (54653) | 54653..54904 | + | 252 | WP_001291965.1 | hypothetical protein | - |
| EXE32_RS26420 (54976) | 54976..55128 | - | 153 | WP_001303307.1 | Hok/Gef family protein | Toxin |
| - (55178) | 55178..55240 | + | 63 | NuclAT_0 | - | Antitoxin |
| - (55178) | 55178..55240 | + | 63 | NuclAT_0 | - | Antitoxin |
| - (55178) | 55178..55240 | + | 63 | NuclAT_0 | - | Antitoxin |
| - (55178) | 55178..55240 | + | 63 | NuclAT_0 | - | Antitoxin |
| EXE32_RS26425 (55449) | 55449..56534 | + | 1086 | WP_250186221.1 | protein finQ | - |
| - (56604) | 56604..56662 | + | 59 | NuclAT_1 | - | - |
| - (56604) | 56604..56662 | + | 59 | NuclAT_1 | - | - |
| - (56604) | 56604..56662 | + | 59 | NuclAT_1 | - | - |
| - (56604) | 56604..56662 | + | 59 | NuclAT_1 | - | - |
| EXE32_RS26430 (56842) | 56842..58050 | + | 1209 | WP_001295719.1 | IncI1-type conjugal transfer protein TrbA | - |
| EXE32_RS26435 (58069) | 58069..59139 | + | 1071 | WP_000151590.1 | IncI1-type conjugal transfer protein TrbB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..71003 | 71003 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5817.21 Da Isoelectric Point: 8.7948
>T118821 WP_001303307.1 NZ_CP035854:c55128-54976 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T118821 NZ_CP035854:c55128-54976 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 63 bp
>AT118821 NZ_CP035854:55178-55240 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
