Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4899482..4899707 Replicon chromosome
Accession NZ_CP035841
Organism Escherichia coli strain TW10722

Toxin (Protein)


Gene name hokW Uniprot ID S1ELB5
Locus tag EXA02_RS24050 Protein ID WP_000813254.1
Coordinates 4899552..4899707 (+) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 4899482..4899540 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EXA02_RS24030 4894947..4896224 + 1278 WP_000625667.1 DUF2254 domain-containing protein -
EXA02_RS24035 4896507..4897202 - 696 WP_032190252.1 hypothetical protein -
EXA02_RS24040 4897205..4897711 - 507 WP_000130123.1 hypothetical protein -
EXA02_RS24045 4897708..4898538 - 831 WP_001399639.1 ParA family protein -
- 4899482..4899540 - 59 - - Antitoxin
EXA02_RS24050 4899552..4899707 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD Toxin
EXA02_RS24055 4899874..4900152 + 279 WP_001410105.1 hypothetical protein -
EXA02_RS24060 4900154..4901200 + 1047 WP_001265103.1 DUF968 domain-containing protein -
EXA02_RS24065 4901213..4901584 + 372 WP_001217451.1 RusA family crossover junction endodeoxyribonuclease -
EXA02_RS24070 4901574..4901927 + 354 WP_000532207.1 antiterminator Q family protein -
EXA02_RS24075 4902134..4903417 - 1284 WP_000123148.1 hypothetical protein -
EXA02_RS24080 4903673..4903867 + 195 WP_001355891.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4868604..4935425 66821


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5736.89 Da        Isoelectric Point: 6.1531

>T118757 WP_000813254.1 NZ_CP035841:4899552-4899707 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Download         Length: 156 bp

>T118757 NZ_CP035841:4899552-4899707 [Escherichia coli]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 59 bp

>AT118757 NZ_CP035841:c4899540-4899482 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TMW0

Antitoxin

Download structure file

References