Detailed information of TA system TA118733

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 1603227..1603639
• Replicon: chromosome
• Accession: NZ_CP035841
• Organism: Escherichia coli strain TW10722

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A3W4M8W4
• Locus tag: EXA02_RS07880
• Protein ID: WP_000132864.1
• Coordinates: 1603298..1603639 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	1603227..1603303 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EXA02_RS07870 (1600171)	1600171..1601760	+	1590	WP_001063214.1	type I restriction-modification system methyltransferase	-
EXA02_RS07875 (1601757)	1601757..1603070	+	1314	WP_000042302.1	restriction endonuclease subunit S	-
- (1603227)	1603227..1603303	-	77	NuclAT_14	-	Antitoxin
- (1603227)	1603227..1603303	-	77	NuclAT_14	-	Antitoxin
- (1603227)	1603227..1603303	-	77	NuclAT_14	-	Antitoxin
- (1603227)	1603227..1603303	-	77	NuclAT_14	-	Antitoxin
- (1603227)	1603227..1603303	-	77	NuclAT_15	-	Antitoxin
- (1603227)	1603227..1603303	-	77	NuclAT_15	-	Antitoxin
- (1603227)	1603227..1603303	-	77	NuclAT_15	-	Antitoxin
- (1603227)	1603227..1603303	-	77	NuclAT_15	-	Antitoxin
EXA02_RS07880 (1603298)	1603298..1603639	+	342	WP_000132864.1	endoribonuclease SymE	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12254.06 Da
• Isoelectric Point: 7.8817

>T118733 WP_000132864.1 NZ_CP035841:1603298-1603639 [Escherichia coli]
MTDTYSIAQPFEAEVSPANNRHVTVGYASRYPDHAHIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRRVCKLSARKQKQVQEFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T118733 NZ_CP035841:1603298-1603639 [Escherichia coli]
ATGACTGACACGTATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCTCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGCCGCTACCCGGATCACGCGCATATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGCATCGTCCTCACCGCTCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCAGGGTGTGCAAGCTGTCGGCGCGTAAACAAAAGCAGGTGCAGGAATTTATTGGGGTGATTGC
CGGTAAACAGAAAGTTGCCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT118733 NZ_CP035841:c1603303-1603227 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A3W4M8W4

Antitoxin