Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 69188..69452 | Replicon | plasmid p67_75 |
| Accession | NZ_CP035830 | ||
| Organism | Escherichia coli strain 67-1 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | E6BRV3 |
| Locus tag | EXA05_RS26555 | Protein ID | WP_001303307.1 |
| Coordinates | 69300..69452 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 69188..69250 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EXA05_RS26540 (65289) | 65289..66359 | - | 1071 | WP_000151590.1 | IncI1-type conjugal transfer protein TrbB | - |
| EXA05_RS26545 (66378) | 66378..67586 | - | 1209 | WP_001295719.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (67766) | 67766..67824 | - | 59 | NuclAT_1 | - | - |
| - (67766) | 67766..67824 | - | 59 | NuclAT_1 | - | - |
| - (67766) | 67766..67824 | - | 59 | NuclAT_1 | - | - |
| - (67766) | 67766..67824 | - | 59 | NuclAT_1 | - | - |
| EXA05_RS26550 (67894) | 67894..68673 | - | 780 | WP_276312874.1 | protein FinQ | - |
| - (69188) | 69188..69250 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (69188) | 69188..69250 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (69188) | 69188..69250 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (69188) | 69188..69250 | - | 63 | NuclAT_0 | - | Antitoxin |
| EXA05_RS26555 (69300) | 69300..69452 | + | 153 | WP_001303307.1 | Hok/Gef family protein | Toxin |
| EXA05_RS26560 (69524) | 69524..69775 | - | 252 | WP_001291965.1 | hypothetical protein | - |
| EXA05_RS27005 (70276) | 70276..70371 | + | 96 | WP_000609148.1 | DinQ-like type I toxin DqlB | - |
| EXA05_RS26570 (70436) | 70436..70612 | - | 177 | WP_001054898.1 | hypothetical protein | - |
| EXA05_RS26575 (71014) | 71014..71223 | + | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
| EXA05_RS26580 (71295) | 71295..71957 | - | 663 | WP_000644795.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| EXA05_RS26585 (72028) | 72028..74196 | - | 2169 | WP_000698356.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..75047 | 75047 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5817.21 Da Isoelectric Point: 8.7948
>T118671 WP_001303307.1 NZ_CP035830:69300-69452 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCVLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T118671 NZ_CP035830:69300-69452 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA
Antitoxin
Download Length: 63 bp
>AT118671 NZ_CP035830:c69250-69188 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
